Ekaterini Chatzaki PhD
 Assistant Professor of Pharmacology

Laboratory of Pharmacology, 
School  of Medicine, Democritus University of Thrace.

Telephone: +3025510-30533/ Fax  +3025510-30533



                 Laboratory of Pharmacology,
                 School of Medicine,
                 Democritus University of Thrace,
                 Dragana, Alexandroupolis,
                 68100, Greece.


Curriculum Vitae: 

 English Ελληνικά


     Research Interests:


  • The involvement of stress and the CRF system in human physiology and pathophysiology of stress-related and other disorders (with emphasis in reproductive and gastrointestinal systems).

  • Physiology and pathophysiology of endometrium, hormonal control, autocrine/paracrine regulatory mechanisms, decidualization, angiogenesis, immune control etc. and the formation of the foetalplacental unit.

  • The role of Gonadotropin Releasing Hormone (GnRH) and its receptors in the normal and malignant growth of the human endometrium.

  • Carcinogenesis and tumour markers of hormone-dependent malignancies and development of gene therapy technology for targeting hormone-dependent malignancies.

  • Autocrine/paracrine effects of opioid peptides in peripheral systems (endometrium, adrenals),

  • Molecular modelling of G-protein coupled receptors (GPCRs).

  • Clinical studies for new anticancer schemes.

  • Safe use of hazardous drugs.


Constantinidis TC, Vagka E, Dallidou P, Basta P, Drakopoulos V, Kakolyris S, Chatzaki E: Occupational health and safety of personnel handling chemotherapeutic agents in Greek hospitals. Eur J Cancer Care (Engl) 2011;20:123-131.

Xenidis N, Neanidis K, Amarantidis K, Dimopoulos P, Chamalidou E, Pitsiava D, Tentes A, Chatzaki E, Karakitsos P, Kakolyris S: Biweekly vinorelbine and gemcitabine as second-line and beyond treatment in ovarian cancer. Cancer Chemother Pharmacol 2011;67:69-73.

Amarantidis K, Xenidis N, Chelis L, Chiotis A, Tentes A, Chatzaki E, Kortsaris A, Polychronidis A, Karakitsos P, Kakolyris S: A dose escalation study of docetaxel plus capecitabine in combination with oxaliplatin in patients with advanced solid tumors. Acta Oncol 2010;49:245-251.

Chelis L, Xenidis N, Amarantidis K, Prassopoulos P, Chamalidou E, Neanidis K, Mikroulis D, Chatzaki E, Karakitsos P, Kakolyris S: Biweekly vinorelbine and gemcitabine as second-line treatment and beyond in non-small cell lung cancer. Chemotherapy 2010;56:353-358.

Kaprara A, Pazaitou-Panayiotou K, Chemonidou MC, Constantinidis TC, Lambropoulou M, Koffa M, Kiziridou A, Kakolyris S, Kortsaris A, Chatzaki E: Distinct distribution of corticotropin releasing factor receptors in human breast cancer. Neuropeptides 2010;44:355-361.

Kaprara A, Pazaitou-Panayiotou K, Kortsaris A, Chatzaki E: The corticotropin releasing factor system in cancer: expression and pathophysiological implications. Cell Mol Life Sci 2010;67:1293-1306.

Lambropoulou M, Papadopoulos N, Tripsianis G, Alexiadis G, Pagonopoulou O, Kiziridou A, Liberis V, Kakolyris S, Chatzaki E: Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients. J Cancer Res Clin Oncol 2010;136:427-435.

Paschos KA, Charsou C, Constantinidis TC, Anagnostoulis S, Lambropoulou M, Papachristou F, Simopoulos K, Chatzaki E: Corticotropin-releasing hormone receptors mediate opposing effects in cholestasis-induced liver cell apoptosis. Endocrinology 2010;151:1704-1712.

Paschos KA, Kolios G, Chatzaki E: The corticotropin-releasing factor system in inflammatory bowel disease: Prospects for new therapeutic approaches. Drug Discov Today 2009;14:713-720.

Paschos KA, Veletza S, Chatzaki E: Neuropeptide and sigma receptors as novel therapeutic targets for the pharmacotherapy of depression. CNS Drugs 2009;23:755-772.

Simopoulos C, Christodoulou E, Lambropoulou M, Tsaroucha AK, Kakolyris S, Polychronidis A, Karayiannakis AJ, Chatzaki E: Neuropeptide urocortin 1 and its receptors are expressed in the human liver. Neuroendocrinology 2009;89:315-326.

Stavroulaki M, Kardassis D, Chatzaki E, Sakellaris G, Lindschau C, Haller H, Tosca A, Krasagakis K: Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta. J Cell Physiol 2008;214:363-370.

Tsaroucha AK, Chatzaki E, Lambropoulou M, Despoudi K, Laftsidis P, Charsou C, Polychronidis A, Papadopoulos N, Simopoulos CE: Megalin and cubilin in the human gallbladder epithelium. Clin Exp Med 2008;8:165-170.

Dermitzaki E, Tsatsanis C, Minas V, Chatzaki E, Charalampopoulos I, Venihaki M, Androulidaki A, Lambropoulou M, Spiess J, Michalodimitrakis E, Gravanis A, Margioris AN: Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner. Endocrinology 2007;148:1524-1538.

Lambropoulou M, Stefanou D, Alexiadis G, Tamiolakis D, Tripsianis G, Chatzaki E, Vandoros GP, Kiziridou A, Papadopoulou E, Papadopoulos N: Cytoplasmic expression of c-erb-B2 in endometrial carcinomas. Onkologie 2007;30:495-500.

Tsatsanis C, Dermitzaki E, Venihaki M, Chatzaki E, Minas V, Gravanis A, Margioris AN: The corticotropin-releasing factor (CRF) family of peptides as local modulators of adrenal function. Cell Mol Life Sci 2007;64:1638-1655.

Amarantidis K, Houhouli K, Papatheodorou K, Miloussis A, Matthaios D, Chatzaki E, Lyrantzopoulos N, Tsaroucha A, Tentes A, Kakolyris S: A dose escalation study of docetaxel plus capecitabine in combination with gemcitabine in patients with advanced solid tumors. Oncol Res 2006;16:281-287.

Charalampopoulos I, Androulidaki A, Minas V, Chatzaki E, Tsatsanis C, Notas G, Xidakis C, Kolios G, Kouroumalis E, Margioris AN, Gravanis A: Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells. Neuroendocrinology 2006;84:49-57.

Chatzaki E, Lambropoulou M, Constantinidis TC, Papadopoulos N, Tache Y, Minopoulos G, Grigoriadis DE: Corticotropin-releasing factor (CRF) receptor type 2 in the human stomach: protective biological role by inhibition of apoptosis. J Cell Physiol 2006;209:905-911.

Chatzaki E, Minas V, Zoumakis E, Makrigiannakis A: CRF receptor antagonists: utility in research and clinical practice. Curr Med Chem 2006;13:2751-2760.

Kaklamanis L, Trichas M, Amarantidis K, Spathari N, Micheli A, Karayiannakis A, Chatzaki E, Georgoulias V, Kakolyris S: VEGF expression in the colorectal adenoma-carcinoma sequence. Oncol Res 2006;15:445-451.

Chatzaki E, Euthymiadis C, Kyriaki S, Lambropoulou M, Tsaroucha A, Laftsidis P, Simopoulos K: Urocortin and corticotropin-releasing hormone receptor type 2 expression in the human gallbladder. Neuroendocrinology 2005;82:177-184.

Maltezos E, Amarantidis K, Trichas M, Vasiliadis M, Toromanidou M, Chatzaki E, Karayiannakis A, Tsaroucha A, Romanidis K, Kakolyris S: A dose escalation study of pegylated liposomal Doxorubicin (caelyx) in combination with capecitabine (xeloda) in patients with refractory solid tumors. Oncology 2005;69:463-469.

Chatzaki E, Crowe PD, Wang L, Million M, Tache Y, Grigoriadis DE: CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon. J Neurochem 2004;90:309-316.

Chatzaki E, Murphy BJ, Wang L, Million M, Ohning GV, Crowe PD, Petroski R, Tache Y, Grigoriadis DE: Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodies. J Neurochem 2004;88:1-11.

Chatzaki E, Kouimtzoglou E, Margioris AN, Gravanis A: Transforming growth factor beta1 exerts an autocrine regulatory effect on human endometrial stromal cell apoptosis, involving the FasL and Bcl-2 apoptotic pathways. Mol Hum Reprod 2003;9:91-95.

Chatzaki E, Charalampopoulos I, Leontidis C, Mouzas IA, Tzardi M, Tsatsanis C, Margioris AN, Gravanis A: Urocortin in human gastric mucosa: relationship to inflammatory activity. J Clin Endocrinol Metab 2003;88:478-483.

Chatzaki E, Margioris AN, Gravanis A: Expression and regulation of corticotropin-releasing hormone binding protein (CRH-BP) in rat adrenals. J Neurochem 2002;80:81-90.

Gravanis A, Makrigiannakis A, Chatzaki E, Zoumakis E, Tsatsanis C, Margioris AN: Stress neuropeptides in the human endometrium: paracrine effects on cell differentiation and apoptosis. Hormones (Athens) 2002;1:139-148.

Chatzaki E, Makrigiannakis A, Margioris AN, Kouimtzoglou E, Gravanis A: The Fas/FasL apoptotic pathway is involved in kappa-opioid-induced apoptosis of human endometrial stromal cells. Mol Hum Reprod 2001;7:867-874.

Krasagakis K, Almond-Roesler B, Geilen C, Fimmel S, Krengel S, Chatzaki E, Gravanis A, Orfanos CE: Growth and characterization of a cell line from a human primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma) in culture and as xenograft. J Cell Physiol 2001;187:386-391.

Zoumakis E, Chatzaki E, Charalampopoulos I, Margioris AN, Angelakis E, Koumantakis E, Gravanis A: Cycle and age-related changes in corticotropin-releasing hormone levels in human endometrium and ovaries. Gynecol Endocrinol 2001;15:98-102.

Chatzaki E, Margioris AN, Makrigiannakis A, Castanas E, Georgoulias V, Gravanis A: Kappa opioids and TGFbeta1 interact in human endometrial cells. Mol Hum Reprod 2000;6:602-609.

Davies S, Bax CM, Chatzaki E, Chard T, Iles RK: Regulation of endometrial cancer cell growth by luteinizing hormone (LH) and follicle stimulating hormone (FSH). Br J Cancer 2000;83:1730-1734.

Dermitzaki E, Chatzaki E, Gravanis A, Margioris AN: Opioids transiently prevent activation of apoptotic mechanisms following short periods of serum withdrawal. J Neurochem 2000;74:960-969.

Makrigiannakis A, Margioris AN, Chatzaki E, Zoumakis E, Chrousos GP, Gravanis A: The decidualizing effect of progesterone may involve direct transcriptional activation of corticotrophin-releasing hormone from human endometrial stromal cells. Mol Hum Reprod 1999;5:789-796.

Bax CM, Chatzaki E, Davies S, Gallagher CJ: Elucidating the role of gonadotrophins in endometrial cancer cell growth. Biochem Soc Trans 1996;24:443S.

Chatzaki E, Bax CM, Eidne KA, Anderson L, Grudzinskas JG, Gallagher CJ: The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res 1996;56:2059-2065.

Chatzaki E, Gallagher CJ, Iles RK, Ind TE, Nouri AM, Bax CM, Grudzinskas JG: Characterisation of the differential expression of marker antigens by normal and malignant endometrial epithelium. Br J Cancer 1994;69:1010-1014.