Vangelis Manolopoulos PhD
 Associate Professor of Pharmacology

Laboratory of Pharmacology, 
School  of Medicine, Democritus University of Thrace.

Telephone: +3025510-30523/ Fax  +3025510-30523



                 Laboratory of Pharmacology,
                 School of Medicine,
                 Democritus University of Thrace,
                 Dragana, Alexandroupolis,
                 68100, Greece.


Curriculum Vitae: 

 English ÅëëçíéêÜ


     Research Interests:


  • Genetic and epigenetic studies in cardiovascular medicine

  • Clinical applications of pharmacogenetics in drug metabolism, cardiovascular disease, diabetes, anticoagulant therapy and psychiatric disease

  • Atherosclerosis

  • Development of novel antiatherosclerotic, lipid-lowering and antioxidant agents

  • Endothelial cell physiology and pathophysiology and anion channel function


Manolopoulos VG, Dechairo B, Huriez A, Kuehn A, Llerena A, Van Schaik R, Yeo J, Ragia G, Siest G, “Fifth Santorini conference pharmacogenomics roundtable report: Pharmacogenomics and personalized medicine in clinical practice” Pharmacogenomics, 12(5):597-610, 2011.

Tavridou A, Ragia G, Manolopoulos VGEmerging targets for the treatment of dyslipidemia  Current Medicinal Chemistry 18(6):909-922, 2011.

Squassina A, Artac M, Manolopoulos VG, Lappa-Manakou C, Karkabouna S, Mitropoulos K, Manchia M, Del Zompï Ì, Patrinos GP. Translation of genetic knowledge into clinical practice: the expectations and realities of pharmacogenomics and personalized medicine” Pharmacogenomics 11(8):1149-1167, 2010.

Ragia G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis G, Bougioukas G, Manolopoulos VG. Endothelial nitric oxide synthase gene polymorphisms -786T>C and 894G>T in coronary artery bypass graft surgery patients” Human Genomics 4(6):1-9, 2010.

Tavridou A, Efthimiadis A, Efthimiadis I, Manolopoulos VG. “Simvastatin-induced changes in circulating oxidized low-density lipoprotein in different types of dyslipidemia” Heart & Vessels 25(4):288-293, 2010.

Verhoef TI, Redekop WK, Darba J, Geitona M, Hughes DA, Siebert U, de Boer A, Maitland-van der Zee A-H, Barallon R, Briz M, Daly A, Haschke-Becher E, Kamali F, Kirchheiner J, Manolopoulos VG, Pirmohamed M, Rosendaal FR, van Schie RMF, Wadelius M. “A systematic review of cost–effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives” Pharmacogenomics 11(7): 989-1002, 2010.

Iordanidou M, Tavridou A, Petridis I, Arvanitidis KI, Christakidis D, Vargemezis V, Manolopoulos VG “The serotonin transporter promoter polymorphism (5-HTTLPR) is associated with type 2 diabetes” Clinica Chimica Acta 411:167-171, 2010.

Iordanidou M, Tavridou A, Petridis I, Kyroglou S, Kaklamanis L, Christakidis D, Manolopoulos VG “Association of polymorphisms of the serotoninergic system  with smoking initiation in Caucasians”, Drug and Alcohol Dependence 108:70-76, 2010.

Donnelly MP, Paschou P, Grigorenko E, Gurwitz D, Mehdi SO, Kajuna SLB, Barta C, Kungulilo S, Karoma NJ, Lu R-Â, Zhukova OV, Kim J-J, Comas D, Siniscalco M, New M, Li P, Li H, Manolopoulos VG, Speed WC, Rajeevan H, Pakstis AJ, Kidd JR, Kidd KK. The Distribution and Most Recent Common Ancestor of the 17q21 Inversion in Humans”. American Journal of Human Genetics 86(2):161-171, 2010.

Manolopoulos VG, Ragia G, Tavridou A  “Pharmacogenetics of Coumarinic Oral Anticïagulants”  Pharmacogenomics 11(4): 493-496, 2010.

Ragia G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis G, Bougioukas G, Manolopoulos VGRenin-angiotensin system gene polymorphisms in coronary artery bypass graft surgery patients” Journal of Renin Angiotensin Aldosterone System 11(2):136-145, 2010.

Ragia G, Arvanitidis KI, Tavridou A, Manolopoulos VG, " Need for reassessment of reported CYP2C19 allele frequencies in various populations in view of CYP2C19*17 discovery: The case of Greece" Pharmacogenomics 10: 43-49, 2009.

Stakos DA, Tavridou A, Margaritis D, Tziakas DN, Kotsianidis I, Chalikias GK, Tsatalas K, Bourikas G, Manolopoulos VG, Boudoulas H “Oxidized low-density lipoprotein and arterial function in beta-thalassemia major” European Journal of Haematology 82: 477-483, 2009.

Tavridou A, Arvanitidis KI, Tiptiri-Kourpeti A, Petridis J, Ragia G, Kyroglou S, Christakidis D, Manolopoulos VG " Thr54 allele of fatty-acid binding protein 2 gene is associated with obesity but not type 2 diabetes mellitus in a Caucasian population” Diabetes Research and Clinical Practice 84(2): 132-137, 2009.

Tavridou A, Manolopoulos VG,EP2300 compounds: focusing on the antiatherosclerotic properties of squalene synthase inhibitors” Current Pharmaceutical Design 15(27): 3167-3178, 2009.

Manolopoulos VG, Tavridou A, “Drugs targeting atherosclerosis: current and emerging approaches” Current Pharmaceutical Design 15(27):3091-3093, 2009. 

Tavridou A, Manolopoulos VG, “Inhibitors of 5-lipoxygenase activating protein (FLAP) –WO2008030369” Expert Opinion on Therapeutic Patents, 19(10): 1473-1476, 2009.

van Schie RMF, Wadelius M, Kamali F, Daly AK, Manolopoulos VG, de Boer A, Barallon R, Verhoef TI, Kirchheiner J, Haschke-Becher E, Briz M, Rosendaal FR, Redekop WK, Pirmohamed M, Maitland-van der Zee A-H, “Genotype-guided dosing of coumarin derivatives: the European pharmacogenomics of anticoagulant therapy (EU-PACT) trial design” Pharmacogenomics 10: 1287-1295, 2009. 

Ragia G, Petridis I, Tavridou A, Christakidis D, Manolopoulos VG, “Presence of CYP2C9*3 allele increases risk for hypoglycemia in type 2 diabetic patients treated with sulphonylurea oral hypoglycemic agents” Pharmacogenomics 10: 1781-1787,  2009.

Tavridou A, Manolopoulos VG. “Novel molecules targeting dyslipidemia and atherosclerosis” Current Medicinal Chemistry 15 (8): 792-802, 2008.

Tavridou A, Kaklamanis L, Papalois A, Kourounakis AP, Rekka E, Kourounakis PN, Charalambus A, Manolopoulos VG, "Antiatherosclerotic properties of EP2302, a novel squalene synthase inhibitor, in the cholesterol-fed rabbit" Journal of Cardiovascular Pharmacology 51(6):573-580, 2008.

M Iordanidou, A Tavridou, MV Vasiliadis, KI Arvanitidis, J Petridis, DA Christakidis, V Vargemezis, G Bougioukas, VG Manolopoulos, “The -759 C/T polymorphism of the 5-HT2C receptor is associated with type II diabetes in male and female Caucasians” Pharmacogenetics & Genomics, 18 (2):153-159, 2008.

A Llerena, G Michel, E Jeannesson, S Wong, VG Manolopoulos, et al. “Third Santorini conference pharmacogenomics workshop report: Pharmacogenomics at the crossroads: What else than good science will be needed for the field to become part of personalized medicine?”. Clinical Chemistry and Laboratory Medicine, 45: 843-850, 2007.

K Arvanitidis, G Ragia, M Iordanidou, S Kyriaki, A Xanthi, A Tavridou and VG Manolopoulos. “Genetic polymorphisms of drug-metabolising enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population”. Fundamental and Clinical Pharmacology, 21 (4): 419-426, 2007. 

A Tavridou, G Megaritis, AP Kourounakis, A Charalambous and VG Manolopoulos. "EP2306 and EP2302, two novel squalene synthase inhibitors, stimulate eNOS expression in cultured endothelial cells" Endothelium, 14 (4): 239-243, 2007.

A Tavridou, L Kaklamanis, A Papalois, AP Kourounakis, EA. Rekka, PN Kourounakis, A Charalambous, VG Manolopoulos, “EP2306, a novel squalene synthase inhibitor, inhibits atherosclerosis in the cholesterol-fed rabbit”. Journal of Pharmacology Experimental Therapeutics, 323(3): 794-804, 2007.

VG Manolopoulos. “Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice”. Clinical Chemistry and Laboratory Medicine, 45: 801-814, 2007.

A Tavridou, L Kaklamanis, G Megaritis, AP Kourounakis, A Papalois, D Roukounas, E. Rekka, PN Kourounakis, A Charalambous, VG Manolopoulos. "Pharmacological characterization in vitro of EP2306 and EP2302, potent inhibitors of squalene synthase and atherosclerosis". European Journal of Pharmacology, 535: 34-42, 2006.

AAK Tentes, SK Markakidis, C Karanikiotis, A Fiska, IK Tentes, VG Manolopoulos, T Dimitriou. “Intra-arterial chemotherapy as an adjuvant treatment in locally advanced gastric cancer”. Langenbeck’s Archives of Surgery, 391: 124-129, 2006.

A Tavridou, VG Manolopoulos. "Atorvastatin and simvastatin decrease the uptake of acetylated-low density lipoprotein by hyman monocytes”, Pharmacology 73: 102-105, 2005.

D Gurwitz, Lunshof J, G Dedoussis, CS Flordellis, U Fuhr, J Kirchheiner, J Licinio, A Llerena, VG Manolopoulos, LJ Sheffield, G Siest, F Torricelli, V Vasiliou, S Wong. “Pharmacogenomics education: International society of pharmacogenomics recommendations for medical, pharmaceutical and health schools deans of education” Pharmacogenomics Journal, 5: 221-225, 2005.

A Tavridou, VG Manolopoulos. "Antioxidant properties of two novel 2-biphenylmorpholine compounds (EP2306 and EP2302) in vitro and in vivo European Journal of Pharmacology 505: 213-221, 2004.

E Papadimitriou, CR Waters, VG Manolopoulos, BR Unsworth, ME Maragoudakis, PI Lelkes, “Regulation of extracellular matrix remodeling and MMP-2 activation in cultured rat adrenal medullary endothelial cells”, Endothelium 8: 181-194, 2001.

VG Manolopoulos, S Liekens, P Koolwijk, T Voets, E Peters, G Droogmans, PI Lelkes, E. De Clercq, B Nilius, “Inhibition of angiogenesis by blockers of volume-regulated anion channels”, General Pharmacology 34: 107-116, 2000.

SH Suh, R Vennekens, VG Manolopoulos, M Freichel, U Schweig, J Prenen, V Flockerzi, G Droogmans, B Nilius, “Characterization of explanted endothelial cells from mouse aorta: electrophysiology and Ca2+-signalling”, Pflügers Archiv European Journal of Physiology 438: 612-620, 1999.

I Mountian, VG Manolopoulos, H De Smedt, JB Parys, L Missiaen, F Wuytack, “Expression patterns of sarco/endoplasmatic reticulum Ca2+-ATPase and inositol 1,4,5-trisphosphate receptor isoforms in vascular endothelial cells”, Cell Calcium 25: 371-380, 1999.

T Voets, V Manolopoulos, J Eggermont, C Ellory, G Droogmans, B Nilius, “Regulation of swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins”, Journal of Physiology (London) 506: 341-352, 1998.

VG Manolopoulos, JW Fenton II, PI Lelkes, "The thrombin receptor in adrenal medullary endothelial cells is negatively coupled to adenylyl cyclase through a Gi-protein" Biochimica Biophysica Acta 1356: 321-332, 1997.

E. Papadimitriou, VG Manolopoulos, GT Hayman, ME Maragoudakis, BR Unsworth, JW Fenton II, PI Lelkes, “Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells”, American Journal of Physiology (Cell Physiology) 272: C1112-C1122, 1997.

VG Manolopoulos, T Voets, PE Declercq, G Droogmans, B Nilius,“Swelling-activated efflux of taurine and other organic osmolytes in endothelial cells”, American Journal of Physiology (Cell Physiology) 273: C214-C222, 1997.

VG Manolopoulos, G Droogmans, B Nilius, “Hypotonicity and thrombin activate taurine efflux in BC3H1 and C2C12 myoblasts that is down regulated during differentiation”, Biochemical Biophysical Research Communications 232: 74-79, 1997.

VG Manolopoulos, J Prenen, G Droogmans, B Nilius, “Thrombin potentiates volume-activated chloride currents in pulmonary artery endothelial cells” Pflügers Archiv European Journal of Physiology 433: 845-847, 1997.

B Nilius, J Eggermont, T Voets, G Buyse, V Manolopoulos, G Droogmans,   “Properties of volume-regulated anion channels in mammalian cells”, Progress in  Biophysics and Molecular Biology 68: 69-119, 1997.

MD Silverman, VG Manolopoulos, BR Unsworth, PI Lelkes, "Tissue factor expression is differentially modulated by cyclic mechanical strain in various human endothelial cells",  Blood, Coagulation, and Fibrinolysis 7: 281-288, 1996.

S Efthimiopoulos, S Punj, V Manolopoulos, M Pangalos, GP Wang, LM Refolo, NK Robakis, "Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein", Journal of Neurochemistry 67: 872-875, 1996.

VG Manolopoulos, MM Samet, PI Lelkes, "Regulation of the adenylyl cyclase signaling system in various types of cultured endothelial cells", Journal of  Cellular Biochemistry  57:590-598, 1995.

VG Manolopoulos, J Liu, BR Unsworth, PI Lelkes, "Adenylyl cyclase isoforms are differentially expressed in primary cultures of endothelial cells and whole tissue homogenates from various rat tissues", Biochemical Biophysical Research Communications 208: 323-331, 1995.

VG Manolopoulos, PI Lelkes, "Cyclic strain and forskolin differentially induce cAMP production in phenotypically diverse endothelial cells", Biochemical Biophysical Research Communications 191: 1379-85, 1993.

VG Manolopoulos, E Pipili-Synetos, A den Hertog, A Nelemans, "Inositol phosphates formed in rat aorta after a1-adrenergic stimulation are inhibited by forskolin", European Journal of Pharmacology 207: 29-36, 1991.

D Synetos, VG Manolopoulos, D Atlas, E Pipili-Synetos, "A human plasma-derived material with clonidine displacing substance (CDS)-like properties, contracts the isolated rat aorta", Journal of Autonomic Pharmacology 11: 343-351, 1991.

E Pipili, VG Manolopoulos, JD Catravas, ME Maragoudakis, "Angiotensin converting enzyme activity is present in the endothelium-denuded aorta", British Journal of Pharmacology 98: 333-335, 1989.