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Publications:
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Manolopoulos
VG,
Dechairo
B,
Huriez
A,
Kuehn
A,
Llerena
A,
Van
Schaik
R,
Yeo
J,
Ragia
G,
Siest
G,
“Fifth Santorini conference pharmacogenomics roundtable report:
Pharmacogenomics and personalized medicine in clinical practice” Pharmacogenomics,
12(5):597-610,
2011.
Tavridou
A,
Ragia
G,
Manolopoulos
VG
“Emerging
targets
for
the
treatment
of
dyslipidemia”
Current
Medicinal
Chemistry
18(6):909-922,
2011.
Squassina
A,
Artac
M, Manolopoulos
VG,
Lappa-Manakou C, Karkabouna S, Mitropoulos K, Manchia M, Del Zompï
Ì,
Patrinos GP. “Translation
of genetic knowledge into clinical practice: the expectations and
realities of pharmacogenomics and personalized medicine” Pharmacogenomics
11(8):1149-1167,
2010.
Ragia
G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis G,
Bougioukas G, Manolopoulos VG.
Endothelial nitric oxide synthase gene polymorphisms -786T>C
and 894G>T in coronary artery bypass graft surgery patients” Human
Genomics 4(6):1-9,
2010.
Tavridou
A, Efthimiadis A, Efthimiadis I, Manolopoulos
VG. “Simvastatin-induced
changes in circulating oxidized low-density lipoprotein in different
types of dyslipidemia” Heart
& Vessels 25(4):288-293,
2010.
Verhoef
TI, Redekop
WK, Darba
J, Geitona
M, Hughes
DA, Siebert
U, de
Boer
A, Maitland-van
der Zee
A-H, Barallon
R, Briz
M, Daly
A, Haschke-Becher
E, Kamali
F, Kirchheiner
J, Manolopoulos
VG,
Pirmohamed
M, Rosendaal
FR, van
Schie
RMF, Wadelius
M. “A
systematic review of cost–effectiveness analyses of pharmacogenetic-guided
dosing in treatment with coumarin derivatives”
Pharmacogenomics
11(7): 989-1002, 2010.
Iordanidou
M, Tavridou A, Petridis I, Arvanitidis KI, Christakidis D, Vargemezis V, Manolopoulos
VG “The serotonin transporter promoter polymorphism (5-HTTLPR)
is associated with type 2 diabetes” Clinica
Chimica Acta 411:167-171,
2010.
Iordanidou
M, Tavridou A, Petridis I, Kyroglou S, Kaklamanis L,
Christakidis D, Manolopoulos
VG “Association of polymorphisms of the serotoninergic system
with smoking initiation in Caucasians”,
Drug
and Alcohol Dependence
108:70-76,
2010.
Donnelly
MP, Paschou P, Grigorenko E, Gurwitz D, Mehdi SO, Kajuna SLB, Barta C,
Kungulilo S, Karoma NJ, Lu R-Â, Zhukova OV, Kim J-J, Comas D,
Siniscalco M, New M, Li P, Li H, Manolopoulos
VG, Speed WC, Rajeevan H, Pakstis AJ, Kidd JR, Kidd KK. “The
Distribution and Most Recent Common Ancestor of the 17q21 Inversion in
Humans”.
American
Journal of Human Genetics
86(2):161-171,
2010.
Manolopoulos
VG,
Ragia G, Tavridou A “Pharmacogenetics
of Coumarinic Oral Anticïagulants”
Pharmacogenomics
11(4): 493-496, 2010.
Ragia
G, Nikolaidis E, Tavridou A, Arvanitidis KI, Kanoni S, Dedoussis G,
Bougioukas G, Manolopoulos VG
“Renin-angiotensin system gene polymorphisms in coronary artery
bypass graft surgery patients” Journal
of Renin Angiotensin Aldosterone System
11(2):136-145, 2010.
Ragia
G, Arvanitidis KI, Tavridou A, Manolopoulos
VG, " Need for reassessment of reported CYP2C19 allele
frequencies in various populations in view of CYP2C19*17 discovery: The
case of Greece" Pharmacogenomics
10:
43-49, 2009.
Stakos
DA, Tavridou A, Margaritis D, Tziakas DN, Kotsianidis I, Chalikias GK,
Tsatalas K, Bourikas G, Manolopoulos VG, Boudoulas H “Oxidized low-density lipoprotein and
arterial function in beta-thalassemia major” European Journal of Haematology
82:
477-483, 2009.
Tavridou
A, Arvanitidis KI,
Tiptiri-Kourpeti
A, Petridis J,
Ragia G, Kyroglou S, Christakidis
D, Manolopoulos
VG
"
Thr54 allele of fatty-acid binding protein 2 gene is associated with
obesity but not type 2 diabetes mellitus in a Caucasian population” Diabetes
Research and Clinical Practice
84(2):
132-137,
2009.
Tavridou
A, Manolopoulos VG,
“EP2300 compounds: focusing on the antiatherosclerotic properties
of squalene synthase inhibitors” Current
Pharmaceutical Design
15(27):
3167-3178,
2009.
Manolopoulos
VG,
Tavridou A, “Drugs
targeting atherosclerosis: current and emerging approaches” Current
Pharmaceutical Design 15(27):3091-3093,
2009.
Tavridou
A, Manolopoulos VG,
“Inhibitors of 5-lipoxygenase activating protein (FLAP)
–WO2008030369” Expert
Opinion on Therapeutic Patents,
19(10):
1473-1476,
2009.
van
Schie RMF, Wadelius M, Kamali F, Daly AK, Manolopoulos VG, de Boer A, Barallon R, Verhoef TI, Kirchheiner J,
Haschke-Becher E, Briz M, Rosendaal FR, Redekop WK, Pirmohamed M,
Maitland-van der Zee A-H, “Genotype-guided dosing of coumarin
derivatives: the European pharmacogenomics of anticoagulant therapy (EU-PACT)
trial design”
Pharmacogenomics 10:
1287-1295,
2009.
Ragia
G, Petridis I, Tavridou A, Christakidis D, Manolopoulos VG, “Presence of
CYP2C9*3 allele increases risk for hypoglycemia in type 2 diabetic
patients treated with sulphonylurea oral hypoglycemic agents” Pharmacogenomics
10:
1781-1787,
2009.
Tavridou
A, Manolopoulos VG. “Novel
molecules targeting dyslipidemia and atherosclerosis” Current Medicinal Chemistry
15
(8): 792-802, 2008.
Tavridou
A, Kaklamanis L, Papalois A, Kourounakis AP, Rekka E, Kourounakis PN, Charalambus A, Manolopoulos VG, "Antiatherosclerotic properties of EP2302, a
novel squalene synthase inhibitor, in the cholesterol-fed rabbit" Journal
of Cardiovascular Pharmacology 51(6):573-580, 2008.
M
Iordanidou, A Tavridou, MV Vasiliadis, KI Arvanitidis, J Petridis, DA
Christakidis, V Vargemezis, G Bougioukas, VG
Manolopoulos, “The -759 C/T polymorphism of the 5-HT2C
receptor is associated with type II diabetes in male and female
Caucasians” Pharmacogenetics
& Genomics,
18 (2):153-159, 2008.
A
Llerena, G Michel, E Jeannesson, S Wong, VG
Manolopoulos, et
al. “Third
Santorini conference pharmacogenomics workshop report: Pharmacogenomics
at the crossroads: What else than good science will be needed for the
field to become part of personalized medicine?”. Clinical Chemistry and Laboratory Medicine, 45: 843-850, 2007.
K
Arvanitidis, G Ragia, M Iordanidou, S Kyriaki, A Xanthi, A Tavridou and VG
Manolopoulos. “Genetic
polymorphisms of drug-metabolising enzymes CYP2D6, CYP2C9, CYP2C19 and
CYP3A5 in the Greek population”. Fundamental
and Clinical Pharmacology,
21
(4):
419-426,
2007.
A
Tavridou, G Megaritis, AP Kourounakis, A Charalambous and VG
Manolopoulos. "EP2306 and EP2302, two novel squalene synthase
inhibitors, stimulate eNOS expression in cultured endothelial cells"
Endothelium,
14
(4): 239-243, 2007.
A
Tavridou, L Kaklamanis, A Papalois, AP Kourounakis, EA. Rekka,
PN Kourounakis, A Charalambous, VG
Manolopoulos, “EP2306, a novel squalene synthase inhibitor,
inhibits atherosclerosis in the cholesterol-fed rabbit”. Journal of Pharmacology Experimental Therapeutics, 323(3):
794-804, 2007.
VG
Manolopoulos.
“Pharmacogenomics and
adverse drug reactions in
diagnostic and clinical practice”. Clinical
Chemistry and Laboratory Medicine,
45: 801-814,
2007.
A
Tavridou, L Kaklamanis, G Megaritis, AP Kourounakis, A Papalois, D
Roukounas, E. Rekka, PN Kourounakis, A Charalambous, VG Manolopoulos. "Pharmacological characterization in vitro of
EP2306 and EP2302, potent inhibitors of squalene synthase and
atherosclerosis". European
Journal of Pharmacology, 535:
34-42,
2006.
AAK
Tentes, SK Markakidis, C Karanikiotis, A Fiska, IK Tentes, VG
Manolopoulos, T Dimitriou. “Intra-arterial chemotherapy as an
adjuvant treatment in locally advanced gastric cancer”. Langenbeck’s
Archives of Surgery, 391: 124-129, 2006.
A
Tavridou, VG Manolopoulos.
"Atorvastatin and simvastatin decrease the uptake of acetylated-low
density lipoprotein by hyman monocytes”,
Pharmacology
73: 102-105, 2005.
D
Gurwitz, Lunshof J, G Dedoussis, CS Flordellis, U Fuhr, J Kirchheiner, J
Licinio, A Llerena, VG
Manolopoulos, LJ Sheffield, G Siest, F Torricelli, V Vasiliou, S
Wong. “Pharmacogenomics education: International society of
pharmacogenomics recommendations for medical, pharmaceutical and health
schools deans of education” Pharmacogenomics
Journal, 5:
221-225, 2005.
A
Tavridou, VG Manolopoulos.
"Antioxidant properties of two novel 2-biphenylmorpholine compounds
(EP2306 and EP2302) in vitro and in vivo” European Journal of Pharmacology
505:
213-221, 2004.
E
Papadimitriou, CR Waters, VG
Manolopoulos, BR Unsworth, ME Maragoudakis, PI Lelkes, “Regulation
of extracellular matrix remodeling and MMP-2 activation in cultured rat
adrenal medullary endothelial cells”,
Endothelium
8: 181-194, 2001.
VG
Manolopoulos,
S Liekens, P Koolwijk, T Voets, E Peters, G Droogmans, PI Lelkes, E. De
Clercq, B Nilius, “Inhibition of angiogenesis by blockers of volume-regulated
anion channels”, General Pharmacology 34:
107-116, 2000.
SH
Suh, R Vennekens, VG Manolopoulos,
M Freichel, U Schweig, J Prenen, V Flockerzi, G Droogmans, B Nilius,
“Characterization of explanted endothelial cells from mouse aorta:
electrophysiology and Ca2+-signalling”,
Pflügers Archiv European
Journal of Physiology
438: 612-620, 1999.
I
Mountian, VG Manolopoulos, H
De Smedt, JB Parys, L Missiaen, F Wuytack, “Expression patterns of
sarco/endoplasmatic reticulum Ca2+-ATPase and inositol
1,4,5-trisphosphate receptor isoforms in vascular endothelial cells”,
Cell
Calcium
25: 371-380, 1999.
T
Voets, V Manolopoulos, J
Eggermont, C Ellory, G Droogmans, B Nilius, “Regulation of swelling-activated
chloride current in bovine endothelium by protein tyrosine
phosphorylation and G proteins”,
Journal of Physiology (London)
506: 341-352, 1998.
VG
Manolopoulos,
JW Fenton II, PI Lelkes, "The thrombin receptor in adrenal
medullary endothelial cells is negatively coupled to adenylyl cyclase
through a Gi-protein" Biochimica
Biophysica Acta 1356: 321-332, 1997.
E.
Papadimitriou, VG Manolopoulos,
GT Hayman, ME Maragoudakis, BR Unsworth, JW Fenton II, PI Lelkes,
“Thrombin modulates vectorial secretion of extracellular matrix
proteins in cultured endothelial cells”,
American
Journal of Physiology (Cell Physiology)
272:
C1112-C1122, 1997.
VG
Manolopoulos,
T Voets, PE Declercq, G Droogmans, B Nilius,“Swelling-activated efflux
of taurine and other organic osmolytes in endothelial cells”, American Journal of Physiology (Cell
Physiology) 273: C214-C222, 1997.
VG
Manolopoulos, G Droogmans, B Nilius, “Hypotonicity and thrombin
activate taurine efflux in BC3H1 and C2C12
myoblasts that is down regulated during differentiation”,
Biochemical Biophysical Research
Communications
232: 74-79, 1997.
VG
Manolopoulos,
J Prenen, G Droogmans, B Nilius, “Thrombin potentiates volume-activated
chloride currents in pulmonary artery endothelial cells” Pflügers Archiv European Journal of Physiology
433:
845-847, 1997.
B
Nilius, J Eggermont, T Voets, G Buyse, V
Manolopoulos, G Droogmans,
“Properties of volume-regulated anion channels in mammalian
cells”,
Progress
in Biophysics and Molecular
Biology
68: 69-119, 1997.
MD
Silverman, VG Manolopoulos,
BR Unsworth, PI Lelkes, "Tissue factor expression is differentially
modulated by cyclic mechanical strain in various human endothelial cells",
Blood, Coagulation, and
Fibrinolysis
7: 281-288, 1996.
S
Efthimiopoulos, S Punj, V Manolopoulos, M Pangalos, GP Wang, LM Refolo, NK Robakis, "Intracellular
cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory
cleavage of amyloid precursor protein",
Journal
of Neurochemistry
67: 872-875, 1996.
VG
Manolopoulos,
MM Samet, PI Lelkes, "Regulation of the adenylyl cyclase
signaling system in various types of cultured endothelial cells", Journal of
Cellular Biochemistry
57:590-598,
1995.
VG
Manolopoulos,
J Liu, BR Unsworth, PI Lelkes, "Adenylyl cyclase isoforms are
differentially expressed in primary cultures of endothelial cells and
whole tissue homogenates from various rat tissues", Biochemical
Biophysical Research Communications
208: 323-331, 1995.
VG
Manolopoulos,
PI Lelkes, "Cyclic strain and forskolin differentially induce cAMP
production in phenotypically diverse endothelial cells", Biochemical
Biophysical Research Communications
191: 1379-85, 1993.
VG
Manolopoulos,
E Pipili-Synetos, A den Hertog, A Nelemans, "Inositol phosphates
formed in rat aorta after a1-adrenergic stimulation are
inhibited by forskolin", European Journal of Pharmacology
207: 29-36, 1991.
D
Synetos, VG Manolopoulos, D
Atlas, E Pipili-Synetos, "A human plasma-derived material with
clonidine displacing substance (CDS)-like properties, contracts the
isolated rat aorta",
Journal
of Autonomic Pharmacology
11: 343-351, 1991.
E
Pipili, VG Manolopoulos, JD
Catravas, ME Maragoudakis, "Angiotensin converting enzyme activity
is present in the endothelium-denuded aorta", British Journal of Pharmacology
98: 333-335, 1989.
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