George Kolios MD, PhD
Professor of Pharmacology

Laboratory of Pharmacology
Faculty of Medicine, Democritus University of Thrace, Greece
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Βίος ἀνεόρταστος μακρὴ ὁδòς ἀπανδόκευτος
--Δημόκριτος
(~460-370 π.Χ.)

Life without feasts is like a long road without an inn
--Democritus
(~460-370 BC)


Contact

Telephone+3025510-30368 / Fax +3025510-30541
Emailgkolios@med.duth.gr
AddressLaboratory of Pharmacology,
Faculty of Medicine,
Democritus University of Thrace,
Dragana, Alexandroupolis,
68100, Greece.

Curriculum Vitae

English      Ελληνικά

Previous Posts

Research Interests

Selected Publications (Last 5 years)

  • Karamitrousis E, Balgkouranidou I, Xenidis N, Amarantidis K, Biziota E, Koukaki T, Trypsianis G, Karayiannakis A, Bolanaki H, Chatzaki E, Kolios G, Lianidou E, Lambropoulou M, Kakolyris S. Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer. Clinical Chemistry and Laboratory Medicine . 2020; Online ahead of print.

  • Varbobitis I, Kokkotis G, Gizis M, Perlepe N, Laoudi E, Bletsa M, Bekiari D, Koutsounas I, Kounadis G, Xourafas V, Lagou S, Kolios G, Papakonstantinou I, Bamias G. The IBD-F Patient Self-Assessment Scale Accurately Depicts the Level of Fatigue and Predicts a Negative Effect on the Quality of Life of Patients with IBD in Clinical Remission. Inflammatory Bowel Diseases . 2020; Aug 7;izaa201.

  • Karatzas E, Zachariou M, Bourdakou MM, Minadakis G, Oulas A, Kolios G, Delis A, Spyrou GM. PathWalks: Identifying pathway communities using a disease-related map of integrated information. Bioinformatics . 2020; 36:4070-4079.

  • Koureta M, Karaglani M, Panagopoulou M, Balgkouranidou I, Papadaki-Anastasopoulou A, Zarouchlioti C, Dekavallas S, Kolios G, Lambropoulou M, Baritaki S, Chatzaki E. Corticotropin Releasing Factor Receptors in breast cancer: Expression and activity in hormone-dependent growth in vitro. Peptides . 2020; 129:170316.

  • Dovrolis N, Michalopoulos G, Theodoropoulos GE, Arvanitidis K, Kolios G, Sechi LA, Eliopoulos AG, Gazouli M. The Interplay between Mucosal Microbiota Composition and Host Gene-Expression is Linked with Infliximab Response in Inflammatory Bowel Diseases. Microorganisms . 2020; 8:438.

  • Gogou M, Kolios G. Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone? Journal of the American College of Nutrition . 2020; 39:261-271.
  • Karaglani M, Tzitzikou E, Tottas S, Kougioumtzis I, Arvanitidis K, Kolios G, Chatzaki E, Drosos GI. Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations. Journal of Orthopaedics . 2019; 19:9-13.

  • Papaioannou VE, Sertaridou EN, Chouvarda IG, Kolios GC, Pneumatikos IN. Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study. Intensive Care Medicine Experimental . 2019; 7:53.

  • Karatzas E, Minadakis G, Kolios G, Delis A, Spyrou GM. A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria. Computational and Structural Biotechnology Journal . 2019; 17:939-945.

  • Mantziaris V, Kolios G. Gut Microbiota, Atherosclerosis, and Therapeutic Targets. Critical Pathways in Cardiology . 2019; 18:139-142.

  • Panagopoulou M, Karaglani M, Balgkouranidou I, Biziota E, Koukaki T, Karamitrousis E, Nena E, Tsamardinos I, Kolios G, Lianidou E, Kakolyris S, Chatzaki E. Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers. Oncogene . 2019; 38:3387-3401.

  • Paspaliaris V, Kolios G. Stem cells in Osteoporosis: From Biology to New Therapeutic Approaches. Stem Cells International . 2019; 1730978:1-16.

  • Gazouli M, Dovrolis N, Franke A, Spyrou GM, Sechi LA, Kolios G. Differential genetic and functional background in inflammatory bowel disease phenotypes of a Greek population: a systems bioinformatics approach. Gut Pathogens . 2019; 11:31.

  • Dovrolis N, Filidou E, Kolios G. Systems biology in inflammatory bowel diseases: on the way to precision medicine. Annals of Gastroenterology . 2019; 32:233-246.

  • Valatas V, Kolios G, Bamias G. GTL1A (TNFSF15) and DR3 (TNFRSF25): a co-stimulatory system of cytokines with diverse functions in gut mucosal immunity. Frontiers in Immunology . 2019; 10:583.

  • Karaglani M, Ragia G, Panagopoulou M, Balgkouranidou I, Nena E, Kolios G, Papanas N, Manolopoulos VG, Chatzaki E. Search for Pharmacoepigenetic Correlations in Type 2 Diabetes Under Sulfonylurea Treatment. Experimental and Clinical Endocrinology & Diabetes . 2019; 25:217-225.

  • Dovrolis N, Kolios G, Spyrou GM, Maroulakou I. Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disorders. Briefings in Bioinformatics . 2019; 20:825-841.

  • Dovrolis N, Drygiannakis I, Filidou E, Kandilogiannakis L, Arvanitidis K, Tentes I, Kolios G, Valatas V. Gut Microbial Signatures Underline Complicated Crohn's Disease but Vary Between Cohorts; An in Silico Approach. Inflammatory Bowel Diseases . 2019; 25:217-225.

  • Panagopoulou M, Karaglani M, Balgkouranidou I, Pantazi C, Kolios G, Kakolyris S, Chatzaki E. Circulating cell-free DNA release in vitro: kinetics, size profiling, and cancer-related gene methylation. Journal of Cellular Physiology . 2019; 234:14079-14089.

  • Tsaousi G, Stavrou G, Fotiadis K, Kotzampassi K, Kolios G. Implementation of phospholipids as pharmacological modalities for postoperative adhesions prevention. European Journal of Pharmacology . 2019; 842:189-196.

  • Karatzas E, Kolios G, Spyrou GM. An Application of Computational Drug Repurposing Based on Transcriptomic Signatures. Methods in Molecular Biology . 2019; 1903:149-177.

  • Tsekoura M, Ioannidou M, Pana ZD, Haidich AB, Antachopoulos C, Iosifidis E, Kolios G, Roilides E. Efficacy and Safety of Echinocandins for the Treatment of Invasive Candidiasis in Children: A Meta-analysis. Pediatric Infectious Disease Journal . 2019; 38:42-49.

  • Sertaridou EN, Chouvarda IG, Arvanitidis KI, Filidou EK, Kolios GC, Pnevmatikos IN, Papaioannou VE. Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study. Annals of Intensive Care . 2018; 8:118.

  • Fasoulakis Z, Kolios G, Papamanolis V, Kontomanolis EN. Interleukins Associated with Breast Cancer. Cureus . 2018; 10:e3549.

  • Ioannidis A, Arvanitidis K, Filidou E, Valatas V, Stavrou G, Michalopoulos A, Kolios G, Kotzampassi K. The Length of Surgical Skin Incision in Postoperative Inflammatory Reaction. Journal of the Society of Laparoendoscopic Surgeons . 2018; 22. pii: e2018.00045.

  • Filidou E, Valatas V, Drygiannakis I, Arvanitidis K, Vradelis S, Kouklakis G, Kolios G, Bamias G. Cytokine Receptor Profiling in Human Colonic Subepithelial Myofibroblasts: A Differential Effect of Th Polarization-Associated Cytokines in Intestinal Fibrosis. Inflammatory Bowel Diseases . 2018; 24:2224-2241.

  • Stavrou G, Arvanitidis K, Filidou E, Fotiadis K, Grosomanidis V, Ioannidis A, Tsaousi G, Michalopoulos A, Kolios G, Kotzampassi K. Combined Enteral and Parenteral Glutamine Supplementation in Endotoxaemic Swine: Effects on Portal and Systemic Circulation Levels. Medical Principles and Practice . 2018; 27:570-578.

  • Papavramidis TS, Stavrou G, Papakostas P, Grosomanidis V, Kokkota S, Michalopoulos A, Kolios G, Kotzampassi K. Displacement of the Intragastric Balloon from the Fundus to the Antrum Results in Enhanced Weight Loss. Obesity Surgery . 2018; 28:2374-2378.

  • Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA. Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study. Clinical Pharmacology and Therapeutics . 2018; 104:317-325.

  • Gogou M, Kolios G. Are therapeutic diets an emerging additional choice in autism spectrum disorder management? World Journal of Pediatrics . 2018; 14:215-223.

  • Karaglani M, Ragia G, Panagopoulou M, Balgkouranidou I, Nena E, Kolios G, Papanas N, Manolopoulos VG, Chatzaki E. Search for Pharmacoepigenetic Correlations in Type 2 Diabetes Under Sulfonylurea Treatment. Experimental and Clinical Endocrinology & Diabetes . 2018; doi: 10.1055/s-0043-121265.

  • Dovrolis N, Kolios G, Spyrou GM, Maroulakou I. Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disorders. Briefings in Bioinformatics . 2017; doi: 10.1093/bib/bbx154.

  • Karatzas E, Bourdakou MM, Kolios G, Spyrou GM. Drug repurposing in idiopathic pulmonary fibrosis filtered by a bioinformatics-derived composite score. Scientific Reports . 2017; 7:12569.

  • Bouros E, Filidou E, Arvanitidis K, Mikroulis D, Steiropoulos P, Bamias G, Bouros D, Kolios G. Lung fibrosis-associated soluble mediators and bronchoalveolar lavage from idiopathic pulmonary fibrosis patients promote the expression of fibrogenic factors in subepithelial lung myofibroblasts. Pulmonary Pharmacology & Therapeutics 2017; 46:78-87.

  • Gogou M, Kolios G. The effect of dietary supplements on clinical aspects of autism spectrum disorder: A systematic review of the literature. Brain & Development . 2017; 39:656-664.
  • Dovrolis N, Kolios G, Spyrou G, Maroulakou I. Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases. Drug Discovery Today . 2017; 22:805-813.

  • Valatas V, Filidou E, Drygiannakis I, Kolios G. Stromal and immune cells in gut fibrosis: the myofibroblast and the scarface. Annals of Gastroenterology . 2017; 30:393-404.

  • Panagopoulou M, Lambropoulou M, Balgkouranidou I, Nena E, Karaglani M, Nicolaidou C, Asimaki A, Konstantinidis T, Constantinidis TC, Kolios G, Kakolyris S, Agorastos T, Chatzaki E. Gene promoter methylation and protein expression of BRMS1 in uterine cervix in relation to high-risk human papilloma virus infection and cancer. Tumour Biology . 2017; 39:1010428317697557.

  • Bamias G, Filidou E, Goukos D, Valatas V, Arvanitidis K, Panagopoulou M, Kouklakis G, Daikos GL, Ladas SD, Kolios G. Crohn's disease-associated mucosal factors regulate the expression of TNF-like cytokine 1A and its receptors in primary subepithelial intestinal myofibroblasts and intestinal epithelial cells. Translational Research . 2017; 180:118-130.e2.

  • Kotanidis L, Nikolettos K, Petousis S, Asimakopoulos B, Chatzimitrou E, Kolios G, Nikolettos N. The use of serum anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) to predict the number of oocytes collected and availability of embryos for cryopreservation in IVF. Journal of Endocrinological Investigation . 2016; 39:1459-1464.

  • Kolios G Animal models of inflammatory bowel disease: how useful are they really? Current Opinion in Gastroenterology . 2016; 32:251-257.
  • Kolios G . Bin1 Antibodies for IBD Therapy: Is Permeability the Answer BAR None? Digestive Diseases and Sciences . 2016; 61:330-331.

© Page maintained by George Kolios; last updated: 03/2017