George Kolios MD, PhD
Professor of Pharmacology

Laboratory of Pharmacology
Faculty of Medicine, Democritus University, Greece

Βίος ἀνεόρταστος μακρὴ ὁδòς ἀπανδόκευτος

Life without feasts is like a long road without an inn


Telephone+3025510-30368 / Fax +3025510-30368
AddressLaboratory of Pharmacology,
Faculty of Medicine,
Democritus University of Thrace,
Dragana, Alexandroupolis,
68100, Greece.

Current Posts & CV

Curriculum Vitae

English      Ελληνικά

Previous Posts

Research Interests

Selected Publications

  • Dovrolis N, Kolios G, Spyrou G, Maroulakou I. Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases. Drug Discovery Today 2017; in press
  • Valatas V, Filidou E, Drygianakis I, Kolios G. Stromal and Immune cells in Gut Fibrosis: the Myofibroblast and the Scarface. Annals of Gastroenterology 2017; in press.
  • Bamias G, Filidou E, Goukos D, Valatas V, Arvanitidis K, Panagopoulou M, Kouklakis G, Daikos G, Ladas SD, Kolios G. Crohn’s Disease-Associated Mucosal Factors Regulate the Expression of TNF-like Cytokine 1A (TL1A) and its Receptors in Primary Subepithelial Intestinal Myofibroblasts and Intestinal Epithelial Cells. Translational Research2017 Feb;180:118-130
  • Kotanidis L, Nikolettos K, Petousis S, Asimakopoulos B, Chatzimitrou E, Kolios G, Nikolettos N. The use of serum anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) to predict the number of oocytes collected and availability of embryos for cryopreservation in IVF. Journal of Endocrinological Investigation 2016; Jul 27. [Epub ahead of print]
  • Kolios G. Animal models of inflammatory bowel disease: how useful are they really? Current Opinion Gastroenterology 2016;32:251-257
  • Kolios G. Bin1 Antibodies for IBD Therapy: Is Permeability the Answer BAR None? Digestive Disease Science 2016;61:330-331.
  • Sertaridou E, Papaioannou V, Kolios G , Pneumatikos I. Gut failure in critical care: old school versus new school. Ann Gastroenterol.2015 Jul-Sep;28(3):309-322. Review.
  • Fotiadis K, Filidou E, Arvanitidis K, Valatas V, Stavrou G, Basdanis G, Paspaliaris V, Kolios G, Kotzampassi K. Intraperitoneal application of phospholipids for the prevention of postoperative adhesions: a possible role of myofibroblasts. J Surg Res2015 Aug;197(2):291-300. doi: 10.1016/j.jss.2015.04.036. Epub 2015 Apr 16.
  • Valatas V, Bamias G, Kolios G. Experimental colitis models: Insights into the pathogenesis of inflammatory bowel disease and translational issues. Eur J Pharmacol. 2015 Jul 15;759:253-64. doi: 10.1016/j.ejphar.2015.03.017. Epub 2015 Mar 23. Review.
  • Drosos I, Tavridou A, Kolios G. New aspects on the metabolic role of intestinal microbiota in the development of atherosclerosis. Metabolism. 2015 Apr;64(4):476-81. doi: 10.1016/j.metabol.2015.01.007. Epub 2015 Jan 22. Review.
  • Lalidou F, Kolios G, Tavridou A, Drosos GI. Bone grafts as carriers for local antibiotic delivery for the treatment and prevention of bone infections. Surg Technol Int. 2014 Nov;25:239-45.
  • Fouka E, Lamprianidou E, Arvanitidis K, Filidou E, Kolios G, Miltiades P, Paraskakis E, Antoniadis A, Kotsianidis I, Bouros D. Low-Dose Clarithromycin Therapy Modulates Th17 Response In Non-Cystic Fibrosis Bronchiectasis Patients. Lung . 2014; 192:849-55.
  • Karampelas T, Argyros O, Sayyad N, Spyridaki K, Pappas C, Morgan K, Kolios G, Millar RP, Liapakis G, Tzakos AG, Fokas D, Tamvakopoulos C. GnRH-Gemcitabine Conjugates for the Treatment of Androgen-Independent Prostate Cancer: Pharmacokinetic Enhancements Combined with Targeted Drug Delivery Bioconjugate Chemistry 2014; 25:813-823.
  • Lalidou F, Kolios G, Drosos GI. Bone Infections and Bone Graft Substitutes for Local Antibiotic Therapy. Surgical Technology International 2014; 24:353-62.
  • Valatas V, Vakas M, Kolios G. The value of experimental models of colitis in predicting efficacy of biologic therapies for inflammatory bowel diseases. Am J Physiol Gastrointest Liver Physiol 2013; 305:G763-G785.
  • Tzouvelekis A, Paspaliaris V, Koliakos G, Ntolios P, Bouros E, Oikonomou A, Zissimopoulos A, Boussios N, Dardzinski B, Gritzalis D, Antoniadis A, Froudarakis M, Kolios G, Bouros D. A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in Idiopathic Pulmonary Fibrosis. Journal of Translational Medicine 2013; 11:171.
  • Kolios G , Moodley Y. Introduction to Stem Cells and Regenerative Medicine. Respiration 2013; 85:3-10.
  • Drosos I, Kolios G. Stem cells in liver regeneration and their potential clinical applications. Stem Cell Reviews and Reports 2013; 9:668-84..
  • Valatas V, He J, Rivollier A, Kolios G, Kitamura K, Kelsall BL. Host-dependent control of early regulatory and effector T cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis. Mucosal Immunology 2013; 6:601-611.
  • Manousou P, Kolios G, Drygiannakis I, Koulentaki M, Pyrovolaki K, Voumvouraki A, Notas G, Bourikas L, Papadaki HA, Kouroumalis E. CXCR3 axis in patients with Primary Biliary Cirrhosis. The effect of Ursodeoxycholic Acid. Clinical & Experimental Immunology 2013; 172:9-15.
  • Chatzaki E, Anton PA, Million M, Lambropoulou M, Costantinidis T, Kolios G, Taché Y, Grigoriadis DE. CRF Receptor 2 in human colonic mucosa: down-regulation in Ulcerative Colitis. World Journal of Gastroenterology 2013; 19:1416-1423.
  • Pazaitou-Panayiotou K, Chemonidou C, Poupi A, Koureta M, Kaprara A, Lambropoulou M, Constantinidis TC, Galaktidou G, Koffa M, Kiziridou A, Kakolyris S, Kolios G, Kortsaris A, Chatzaki E. Gonadotropin-Releasing Hormone neuropeptides and receptor in human breast cancer: correlation to poor prognosis parameters. Peptides 2013; 42:15-24.
  • Balgkouranidou I, Karayiannakis A, Matthaios D, Bolanaki H, Tripsianis G, Tentes AA, Lianidou E, Chatzaki E, Fiska A, Lambropoulou M, Kolios G, Kakolyris S. Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. Association with prognostic variables and survival. Clinical Chemistry and Laboratory Medicine 2013; in press.
  • Drygiannakis I, Valatas V, Sfakianaki O, Bourikas L, Manousou P, Kambas K, Ritis K, Kolios G, Kouroumalis E. Proinflammatory cytokines induce crosstalk between colonic epithelial cells and subepithelial myofibroblasts: implication in intestinal fibrosis. Journal of Crohn's and Colitis 2013; 7:286-300.
  • Domvri K, Zarogoulidis P, Porpodis K, Koffa M, Lambropoulou M, Kakolyris S, Kolios G, Zarogoulidis K, Chatzaki E. Gene therapy in liver diseases: State-of-the-art and future perspectives.Cur rent Gene Therapy 2012; 12:463-483.
  • Kolios G , Lira SA. Chemokines and their receptors in gut homeostasis and disease. Current Immunology Reviews 2011; 7:271-279.
  • Tzouvelekis A, Bouros E, Oikonomou A, Ntolios P, Zacharis G, Kolios G, Bouros D. Effect and safety of mycophenolate mofetil in idiopathic pulmonary fibrosis. Pulmonary Medicine. 2011; 2011:849035.
  • Tzouvelekis A, Koliakos G, Ntolios P, Baira I, Bouros E, Oikonomou A, Zissimopoulos A, Kolios G, Kakagia D, Paspaliaris V, Kotsianidis I, Froudarakis, M, Bouros D. Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal. Journal of Translational Medicine. 2011 Oct 21; 9:182.
  • Chrysanthopoulou A, Mitroulis I, Kambas K, Skendros P, Kourtzelis I, Vradelis, S, Kolios G, Aslanidis S, Doumas M, Ritis K. Tissue factor-thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through up-regulation of endothelin receptor A. Arthritis & Rheumatism. 2011; 63:3586-97.
  • Kambas K, Chrysanthopoulou A, Kourtzelis I, Skordala M, Mitroulis I, Rafail S, Vradelis S, Sigalas I, Wu YQ, Speletas M, Kolios G, Ritis K. Endothelin-1 signaling promotes fibrosis in vitro in a bronchopulmonary dysplasia model by activating the extrinsic coagulation cascade. Journal of Immunology 2011; 186:6568-6575.
  • Tsagarakis NJ, Drygiannakis I, Batistakis AG, Kolios G, Kouroumalis EA. Octreotide induces caspase activation and apoptosis in human hepatoma cells (HepG2). World Journal of Gastroenterology. 2011; 17: 313-321.
  • Manousou P, Kolios G, Valatas V, Drygiannakis I, Bourikas L, Pyrovolaki K, Koutroubakis I, Papadaki HA, Kouroumalis E. Increased expression of Chemokine receptor CCR3 and its ligands in ulcerative colitis; the role of colonic epithelial cells in in vitro studies.Clinical & Experimental Immunology 2010; 162: 337–347.
  • Kapetanakis S, Drygiannakis I, Kazakos K, Papanas N, Kolios G, Kouroumalis E, Verettas DA. Serum TGF-â 2 and TGF-â 3 are increased and positively correlated to pain, functionality and radiographic staging in osteoarthritis. Orthopedics; 2010; 33:551.
  • Tsagarakis NJ, Drygiannakis I, Batistakis AG, Kolios G, Kouroumalis EA. A concentration dependent effect of Ursodeoxycholate on apoptosis and caspases activities of HepG2 hepatocellular carcinoma cells. European Journal of Pharmacology 2010; 640: 1-7.
  • Bourikas LA, Kolios G, Valatas V, Notas G, Drygiannakis I, Pelagiadis I, Manousou P, Klironomos S, Mouzas IA, Kouroumalis E. Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. British Journal of Pharmacology 2009; 157:362-370.
  • Galazios G, Papazoglou D, Tsikouras P, Kolios G. Vascular endothelial growth factor gene polymorphisms and pregnancy.Journal of Maternal-Fetal & Neonatal Medicine 2009; 22:371-378.
  • Kotzampassi K, Kolios G, Manousou P, Kazamias P, Paramythiotis D, Papavramidis TS, Heliadis S, Kouroumalis E, Eleftheriadis E. Oxidative stress due to anesthesia and surgical trauma: Importance of early enteral nutrition. Molecular Nutrition & Food Research 2009; 53:770-779.
  • Paschos KA, Kolios G, Chatzaki E. The corticotropin-releasing factor system in inflammatory bowel disease: Prospects for new therapeutic approaches. Drug Discovery Today 2009; 14:713-720.
  • Kefalakes E, Stylianides TJ, Amanakis G, Kolios G. Exacerbation of Inflammatory Bowel Diseases associated with the use of nonsteroidal anti-inflammatory drugs: Myth or Reality? European Journal of Clinical Pharmacology 2009; 65:963-70.
  • Damaskos D, Kolios G. Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope'. British Journal of Clinical Pharmacology 2008; 65:453-467.
  • Kolios G, Valatas V, Manousou P, Xidakis C, Notas G, Kouroumalis E. Nitric oxide and MCP-1 regulation in LPS activated rat Kupffer cells. Molecular and Cellular Biochemistry 2008; 319:91-98.
  • Manousou P, Kolios G, Drygiannakis I, Pyrovolaki K, Bourikas L, Papadaki HA, Kouroumalis E. Expression of a splice variant of CXCR3 in Crohn's disease patients; indication for a lymphocyte-epithelial cell interaction. Journal of Gastroenterology and Hepatology 2008; 23:1823-1833.
  • Kolios G, Kotzampassi K, Manousou P, Paramythiotis D, Papanastasiou H, Drygiannakis I, Notas G, Tsagarakis N, Eleftheriadis E, Kouroumalis E. Enteral nutrition affects nitric oxide production in peripheral blood and liver after a postoperative lipopolysaccharide-induced endotoxemia in rats. Nutrition 2007; 23:575-581.
  • Xidakis C, Mastrodimou N, Notas G, Renieri E, Kolios G, Kouroumalis E, Thermos K. RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells. Regulatory Peptides 2007; 143:76-82.
  • Charalampopoulos I, Androulidaki A, Minas V, Chatzaki E, Tsatsanis C, Notas G, Xidakis C, Kolios G, Kouroumalis E, Margioris AN, Gravanis A. Neuropeptide urocortin and its receptors are expressed in rat kupffer cells.Neuroendocrinology 2006; 84:49-57.
  • Kolios G, Valatas V, Kouroumalis E. Role of Kupffer cells in the pathogenesis of liver disease. World Journal of Gastroenterology 2006; 12:7413-7420.
  • Kolios G, Manousou P, Bourikas L, Notas G, Tsagarakis N, Mouzas I, Kouroumalis E. Ciprofloxacin inhibits cytokine-induced nitric oxide production in human colonic epithelium. European Journal of Clinical Investigation 2006; 36:720-729.
  • Linehan JD, Kolios G, Valatas V, Robertson DA, Westwick J. Effect of corticosteroids on nitric oxide production in inflammatory bowel disease: are leukocytes the site of action? American Journal Physiology - Gastrointestinal & Liver Physiology 2005; 288:G261-G267.
  • Xidakis C, Ljumovic D, Manousou P, Notas G, Valatas V, Kolios G, Kouroumalis E. Production of pro- and anti-fibrotic agents by rat Kupffer cells; the effect of octreotide. Digestive Diseases and Sciences 2005; 50:935-941.
  • Kouroumalis A, Aptel H, Nibbs RJ, Wright KL, Kolios G, Ward SG. The chemokines CXCL9, CXCL10 and CXCL11 differentially stimulate Gái-independent signalling and actin responses in human intestinal myofibroblasts. The Journal of Immunology 2005; 175: 5403–5411.
  • Linehan JD, Kolios G, Valatas V, Robertson DA, Westwick J. Immunomodulatory cytokines suppress epithelial nitric oxide production in inflammatory bowel disease by acting on mononuclear cells. Free Radical Biology & Medicine 2005; 39:1560-1569.
  • Dimoulios P, Kolios G, Notas G, Matrella E, Xidakis C, Koulentaki M, Tsagarakis N, Kouroumalis A, Kouroumalis E. Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis. Alimentary Pharmacology & Therapeutics 2005; 21: 227-234.
  • Kolios G, Valatas V, Ward SG. Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology 2004; 113: 427-437.
  • Vasilaki A, Papadaki T, Notas G, Kolios G, Hoyer D, Tsilimbaris M, Kouroumalis E, Pallikaris I, Thermos K. Effect of somatostatin on nitric oxide production in human retinal pigment epithelium cell cultures. Investigative Ophthalmology & Visual Science 2004; 45:1499-1506.
  • Valatas V, Kolios G, Notas G, Xidakis C, Ljumovic D, Kouroumalis EA. Secretion of inflammatory mediators by isolated rat Kupffer cells; The effect of Octreotide. Regulatory Peptides 2004; 120:215-225.
  • Valatas V, Kolios G, Manousou P, Notas G, Xidakis C, Diamantis I, Kouroumalis E. Octreotide regulates CC but not CXC LPS-induced chemokine secretion in rat Kupffer cells. British Journal of Pharmacology 2004, 141:477-487.
  • Wright KL, Weaver SA, Patel K, Coopman K, Feeney M, Kolios G, Robertson DAF, Ward SG. Differential regulation of prostaglandin E biosynthesis by interferon-g in colonic epithelial cells. British Journal of Pharmacology 2004; 141:1091–1097.
  • Notas G, Kolios G, Mastrodimou N, Kampa M, Vasilaki A, Xidakis C. Castanas E, Thermos K, Kouroumalis E. Cortistatin production by HepG2 human hepatocellular carcinoma cell line and distribution of Somatostatin receptors. Journal of Hepatology 2004; 40:792-798.
  • Valatas V, Xidakis C, Roumpaki H, Kolios G, Kouroumalis EA. Isolation of Rat Kupffer Cells; A Combined Methodology for Highly Purified Primary Cultures. Cell Biology International 2003, 27:67-73.
  • Kolios G, Valatas V, Psilopoulos D, Petraki K, Kouroumalis E. Depletion of non specific esterase activity in the colonic mucosa of patients with ulcerative colitis. European Journal of Clinical Investigation 2002, 32:265-273.
  • Weaver SA, Russo MP, Wright KL, Kolios G, Jobin C, Robertson DA, Ward SG. Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells. Gastroenterology 2001, 120:1117-27.
  • Kolios G, Wright KL, Jordan NJ, Leithead JB, Robertson DAF, Westwick J: C-X-C and C-C chemokine expression and secretion by the human colonic epithelial cell line, HT-29: Differential effect of T-lymphocyte derived cytokines. European Journal of Immunology 1999; 29: 530-536.
  • Wright KL, Kolios G, Westwick J, Ward SG. Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation: evidence for an Interleukin-13-driven Phosphatidyl-inositol 3-kinase-dependent survival mechanism. Journal of Biological Chemistry 1999, 274:17193-17201.
  • Jordan NJ, Kolios G, Abbot SE, Sinai MA, Thompson DA, Petraki K, Westwick J. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. Journal of Clinical Investigation 1999, 104:1061-1069.
  • Davis AMJ, Kolios G, Alveyn CG, Robertson DAF. Antibiotic profylaxis for ERCP: a comparison of oral ciprofloxacin with intravenous cephazolin in the prophylaxis of high risk patients. Alimentary Pharmacology & Therapeutics 1998; 12:207-211.
  • Kolios G, Rooney N, Murphy CT, Robertson DAF, Westwick J. Expression of inducible nitric oxide synthase (iNOS) in human colon epithelial cells: Modulation by T-lymphocyte derived cytokines. Gut 1998; 43:56-63.
  • Wright KL, Ward SG, Kolios G, Westwick J. Activation of Phosphoinositide 3-Kinase by interleukin-13: An inhibitory signal for iNOS expression in an epithelial cell line HT-29. Journal of Biological Chemistry 1997; 272:12626-12633.
  • Kolios G, Robertson DAF, Jordan NJ, Minty A, Caput D, Ferrara P, Westwick J. Interleukin-8 production by the human colon epithelial cell line HT-29: Modulation by Interleukin-13. British Journal of Pharmacology 1996; 119:351-359.
  • Kolios G, Kaloterakis A, Filiotou A, Nakos A, Hadziyannis S. Gastroscopic findings in Mediterranean Kaposi's sarcoma (non-AIDS). Gastrointestinal Endoscopy 1995; 42:336-339.
  • Kolios G, Brown Z, Robson RL, Robertson DAF, Westwick J. Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29. British Journal of Pharmacology 1995; 116:2866-2872.

© Page maintained by George Kolios; last updated: 03/2017