Made with Sparkle

Laboratory of Developmental Biology & Molecular Neurobiology

Maria E. Grigoriou

Associate Professor of Molecular – Developmental Biology

Department of Molecular Biology & Genetics

Democritus University of Thrace



The main research interest of our group is to study the mechanisms underlying mammalian forebrain development.

Our work is focused on: a) the expression and the role of the GRG family of co-repressors and their partners in neurogenesis and differentiation of the ventral telencephalon. b) the function of HSPC280 in cell cycle exit and neuronal differentiation.

Experimental approaches: We use molecular, biochemical and cellular approaches: cultures, protein biochemistry, RNA microarray analysis, real time-PCR, next generation sequencing, histology and imaging.


Recent Publications


  • Stylianopoulou E., Kalamakis G., Pitsiani M., Fysekis I., Ypsilantis P., Simopoulos C., Skavdis G. & Grigoriou M. (2016) HSPC280, a winged helix protein expressed in the subventricular zone of the developing ganglionic eminences, inhibits neuronal differentiation. Histochem Cell Biol. 145 (2), 175-184.
  • Poulatsidou K.N., Lagoudaki R., Touloumi O., Kesidou E., Boziki M., Ravanidis S., Chlichlia K., Grigoriou M. & Grigoriadis N. (2015) Immunophenotype of mouse cerebral hemispheres-derived neural precursor cells. Neurosci Lett. 611: 33-39. doi: 10.1016/j.neulet.2015.11.011.
  • Ravanidis S., Poulatsidou K.N., Lagoudaki R., Touloumi O., Polyzoidou E., Lourbopoulos A., Nousiopoulou E., Theotokis P., Kesidou E., Tsalikakis D., Karacostas D., Grigoriou M., Chlichlia K. & Grigoriadis N. (2015) Subcutaneous Transplantation of Neural Precursor Cells in Experimental Autoimmune Encephalomyelitis Reduces Chemotactic Signals in the Central Nervous System. Stem Cells Transl Med. pii: sctm.2015-0068.
  • Stylianopoulou E, Skavdis G & Grigoriou M. Zinc-based fixation for high-sensitivity in situ hybridization: a nonradioactive colorimetric method for the detection of rare transcripts on tissue sections. (2014) Methods Mol Biol. 1211: 125-38. doi: 10.1007/978-1-4939-1459-3_11.
  • Sadikoglou E, Daoutsali E, Petridou E, Grigoriou M & Skavdis G. Comparative analysis of internal ribosomal entry sites as molecular tools for bicistronic expression. (2014) J Biotechnol. 181: 31-4. doi: 10.1016/j.jbiotec.2014.03.033.
  • Stylianopoulou E., Lykidis D., Ypsilantis P., Simopoulos C., Skavdis G. & Grigoriou M. (2012) A rapid and highly sensitive method of non radioactive colorimetric in situ hybridization for the detection of mRNA on tissue sections. PLoS ONE 7(3): e33898. doi:10.1371/journal.pone.0033898.
  • Paschou P., Stylianopoulou E. Karagiannidis J., Rizzo R., Tarnok Z., Wolanczyk T., Hebebrand J., Nöthen M.J., Lehmkuhl G., Farkas L., Nagy P., Szymanska U., Lykidis D., Androutsos C., Tsironi V., Koumoula A., Barta C., Ypsilantis P., Simopoulos C., TSGeneSEE, Skavdis G. & Grigoriou M. (2012) Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette Syndrome. Genes, Brain and Behaviour, Mar 21. doi: 10.1111/j.1601-183X.2012.00778.x


Address: Department of Molecular Biology & Genetics, University Campus, Alexandroupolis,   Dragana 68100, GREECE                

Web page:

E-mail:  mgrigor@mbg.duth. gr

Phone: +30 25510-30657 (office) +30 25510-30674 (lab)

Fax:  +30 25510-30657 (office)

E-mail:  mgrigor@mbg.duth. gr

Phone: +30 25510-30657 (office) +30 25510-30674 (lab)

Fax:  +30 25510-30657 (office)