George Kolios MD, PhD
Professor of Pharmacology

Principal Investigator
BBMRI (Biobanking and Biomolecular Resources Research Infrastructure), National Strategic Reference Framework, Greece/European Union (2013 - 2023);
“Study of anti-inflammatory and/or anti-fibrotic properties of newly synthesized peptides” (Tithon Biotech Inc, San Diego, California, USA) (2019 - 2025).
Faculty of Medicine, Democritus University of Thrace, Greece.

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Βίος ἀνεόρταστος μακρὴ ὁδòς ἀπανδόκευτος --Δημόκριτος (~460-370 π.Χ.)

Life without feasts is like a long road without an inn --Democritus (~460-370 BC)


Curriculum Vitae

English      Ελληνικά

Previous Posts

Research Interests

Selected Publications (Last 5 years)

  • Kolios G, Paspaliaris V. Mesenchyme Stem Cell-Derived Conditioned Medium as a Potential Therapeutic Tool in Idiopathic Pulmonary Fibrosis. Biomedicines . 2022; 10:2298.

  • Gaitanidis A, Kandilogiannakis L, Filidou E, Tsaroucha A, Kolios G, Pitiakoudis M. Stem cell therapies for gastrointestinal anastomotic healing: a systematic review and meta-analysis on results from animal studies. European Surgical Research . 2022; in press.

  • Spathakis M, Filidou E, Pappa C, Arzou BC, Georgiadis A, Kontomanolis EN, Nikolettos N, Kolios G, Galazios G, Arvanitidis K. Spontaneous abortion is associated with differentially expressed angiogenic chemokines in placenta and decidua. Archives of Gynecology and Obstetrics . 2022; in press.

  • Papadopoulos C, Mimidis K, Papazoglou D, Kolios G, Tentes I, Anagnostopoulos K. Red Blood Cell-Conditioned Media from Non-Alcoholic Fatty Liver Disease Patients Contain Increased MCP1 and Induce TNF-α Release. Reports of Biochemistry and Molecular Biology . 2022; 11:54-62.

  • Tarapatzi G, Filidou E, Kandilogiannakis L, Kolios G, Vradelis S. Biomarkers in Inflammatory Bowel Diseases: Predicting the Indication and the Effect of Biologics. Journal of Gastrointestinal and Liver Diseases . 2022; 31:229-243.

  • Filidou E, Kandilogiannakis L, Tarapatzi G, Spathakis M, Steiropoulos P, Mikroulis D, Arvanitidis K, Paspaliaris V, Kolios G. Anti-Inflammatory and Anti-Fibrotic Effect of Immortalized Mesenchymal-Stem-Cell-Derived Conditioned Medium on Human Lung Myofibroblasts and Epithelial Cells. International Journal of Molecular Sciences . 2022; 23:4570.

  • Papadopoulos C, Spourita E, Mimidis K, Kolios G, Tentes I, Anagnostopoulos K. Non-alcoholic Fatty Liver Disease Patients Exhibit Reduced CD47 and Increased Sphingosine, Cholesterol, and Monocyte Chemoattractant Protein-1 Levels in the Erythrocyte Membranes. Metabolic Syndrome Related Disorders . 2022; 20:377-383.

  • Gazouli M, Dovrolis N, Bourdakou MM, Gizis M, Kokkotis G, Kolios G, Michalopoulos G, Michopoulos S, Papaconstantinou I, Tzouvala M, Viazis N, Xourafas V, Zacharopoulou E, Zampeli E, Mantzaris G, Papatheodoridis G, Bamias G. Response to Anti-α4β7 Blockade in Patients with Ulcerative Colitis is Associated with Distinct Mucosal Gene Expression Profiles at Baseline. Inflammatory Bowel Diseases . 2022; 28:87-95.

  • Filidou E, Tarapatzi G, Spathakis M, Papadopoulos P, Papadopoulos C, Kandilogiannakis L, Stavrou G, Doumaki E, Sioga A, Meditskou S, Arvanitidis K, Papamitsou T, Grosomanidis V, Kolios G, Kotzampassi K. Post-Cardiac Arrest Syndrome Is Not Associated with An Early Bacterial Translocation. Journal of Surgical Research . 2022; 272:51-60.

  • Filidou E, Kolios G. Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?. Pharmaceuticals . 2021; 14(11):1181.

  • Filidou E, Kandilogiannakis L, Tarapatzi G, Su C, Po ENF, Paspaliaris V, Kolios G. Conditioned medium from a human adipose-derived stem cell line ameliorates inflammation and fibrosis in a lung experimental model of idiopathic pulmonary fibrosis. Life Sciences . 2021; 287:120123.

  • Bourdakou MM, Spyrou GM, Kolios G. Colon Cancer Progression ιs Reflected to Monotonic Differentiation in Gene Expression and Pathway Deregulation Facilitating Stage-specific Drug Repurposing. Cancer Genomics Proteomics . 2021; 18: 757-769.

  • Koutouratsas T, Philippou A, Kolios G, Koutsilieris M, Gazouli M. Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review. World Journal of Gastroenterology . 2021; 27: 5037-5046.

  • Kandilogiannakis L, Filidou E, Drygiannakis I, Tarapatzi G, Didaskalou S, Koffa M, Arvanitidis K, Bamias G, Valatas V, Paspaliaris V, Kolios G. Development of a Human Intestinal Organoid Model for In Vitro Studies on Gut Inflammation and Fibrosis. Stem Cells International . 2021; 2021:9929461.

  • Tomazou M, Bourdakou MM, Minadakis G, Zachariou M, Oulas A, Karatzas E, Loizidou E, Kakouri A, Christodoulou C, Savva K, Zanti M, Onisiforou A, Afxenti S, Richter J, Christodoulou CG, Kyprianou T, Kolios G, Dietis N, Spyrou GM. Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19. Briefings in Bioinformatics . 2021; 2021:9929461.

  • Karamitrousis EI, Balgkouranidou I, Xenidis N, Amarantidis K, Biziota E, Koukaki T, Trypsianis G, Karayiannakis A, Bolanaki H, Kolios G, Lianidou E, Kakolyris S. Prognostic Role of RASSF1A, SOX17 and Wif-1 Promoter Methylation Status in Cell-Free DNA of Advanced Gastric Cancer Patients. Technology in Cancer Research and Treatment . 2021; 20:1533033820973279.

  • Karatzas E, Kakouri AC, Kolios G, Delis A, Spyrou GM. Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action. PLoS One . 2021;16:e0249687.

  • Galaziou A, Filidou E, Spathakis M, Arvanitidis K, Arzou BC, Galazios G, Koutlaki N, Nikolettos N, Kolios G. Imbalance of growth factors mRNA expression associated with oxidative stress in the early pregnancy loss. The Journal of Maternal-Fetal & Neonatal Medicine . 2021; Apr 5;1-7.

  • Kokona D, Spyridakos D, Tzatzarakis M, Papadogkonaki S, Filidou E, Arvanitidis KI, Kolios G, Lamani M, Makriyannis A, Malamas MS, Thermos K. The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity. Neuropharmacology . 2021; 185:108450.

  • Kandilogiannakis L, Filidou E, Kolios G, and Paspaliaris V. Ad-Dressing Stem Cells: Hydrogels for Encapsulation. Processes . 2021; 9,11.

  • Theodorakis SG, Kolios G, Tzilas V, Bouros D. Influence of inhalation device, active substance, and drug formulation on the compliance of patients with obstructive pulmonary diseases. A physicians' perspective. Pulmonology . 2020; S2531-0437(20)30255-5.

  • Touzopoulos P, Arvanitidis K, Filidou E, Tilkeridis K, Karanikas M, Kolios G, Ververidis A. Is serum gentamicin concentration modified with autologous cell-saved blood transfusion after total knee arthroplasty using tranexamic acid? A randomized control trial. Orthopaedics & Traumatology: Surgery & Research . 2020; 107(3):102794.

  • Karamitrousis E, Balgkouranidou I, Xenidis N, Amarantidis K, Biziota E, Koukaki T, Trypsianis G, Karayiannakis A, Bolanaki H, Chatzaki E, Kolios G, Lianidou E, Lambropoulou M, Kakolyris S. Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer. Clinical Chemistry and Laboratory Medicine . 2020; 59(2):e73-e75.

  • Varbobitis I, Kokkotis G, Gizis M, Perlepe N, Laoudi E, Bletsa M, Bekiari D, Koutsounas I, Kounadis G, Xourafas V, Lagou S, Kolios G, Papakonstantinou I, Bamias G. The IBD-F Patient Self-Assessment Scale Accurately Depicts the Level of Fatigue and Predicts a Negative Effect on the Quality of Life of Patients with IBD in Clinical Remission. Inflammatory Bowel Diseases . 2020; Aug 7;izaa201.

  • Karatzas E, Zachariou M, Bourdakou MM, Minadakis G, Oulas A, Kolios G, Delis A, Spyrou GM. PathWalks: Identifying pathway communities using a disease-related map of integrated information. Bioinformatics . 2020; 36:4070-4079.

  • Koureta M, Karaglani M, Panagopoulou M, Balgkouranidou I, Papadaki-Anastasopoulou A, Zarouchlioti C, Dekavallas S, Kolios G, Lambropoulou M, Baritaki S, Chatzaki E. Corticotropin Releasing Factor Receptors in breast cancer: Expression and activity in hormone-dependent growth in vitro. Peptides . 2020; 129:170316.

  • Dovrolis N, Michalopoulos G, Theodoropoulos GE, Arvanitidis K, Kolios G, Sechi LA, Eliopoulos AG, Gazouli M. The Interplay between Mucosal Microbiota Composition and Host Gene-Expression is Linked with Infliximab Response in Inflammatory Bowel Diseases. Microorganisms . 2020; 8:438.

  • Gogou M, Kolios G. Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone? Journal of the American College of Nutrition . 2020; 39:261-271.
  • Karaglani M, Tzitzikou E, Tottas S, Kougioumtzis I, Arvanitidis K, Kolios G, Chatzaki E, Drosos GI. Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations. Journal of Orthopaedics . 2019; 19:9-13.

  • Papaioannou VE, Sertaridou EN, Chouvarda IG, Kolios GC, Pneumatikos IN. Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study. Intensive Care Medicine Experimental . 2019; 7:53.

  • Karatzas E, Minadakis G, Kolios G, Delis A, Spyrou GM. A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria. Computational and Structural Biotechnology Journal . 2019; 17:939-945.

  • Mantziaris V, Kolios G. Gut Microbiota, Atherosclerosis, and Therapeutic Targets. Critical Pathways in Cardiology . 2019; 18:139-142.

  • Panagopoulou M, Karaglani M, Balgkouranidou I, Biziota E, Koukaki T, Karamitrousis E, Nena E, Tsamardinos I, Kolios G, Lianidou E, Kakolyris S, Chatzaki E. Circulating cell-free DNA in breast cancer: size profiling, levels, and methylation patterns lead to prognostic and predictive classifiers. Oncogene . 2019; 38:3387-3401.

  • Paspaliaris V, Kolios G. Stem cells in Osteoporosis: From Biology to New Therapeutic Approaches. Stem Cells International . 2019; 1730978:1-16.

  • Gazouli M, Dovrolis N, Franke A, Spyrou GM, Sechi LA, Kolios G. Differential genetic and functional background in inflammatory bowel disease phenotypes of a Greek population: a systems bioinformatics approach. Gut Pathogens . 2019; 11:31.

  • Dovrolis N, Filidou E, Kolios G. Systems biology in inflammatory bowel diseases: on the way to precision medicine. Annals of Gastroenterology . 2019; 32:233-246.

  • Valatas V, Kolios G, Bamias G. GTL1A (TNFSF15) and DR3 (TNFRSF25): a co-stimulatory system of cytokines with diverse functions in gut mucosal immunity. Frontiers in Immunology . 2019; 10:583.

  • Karaglani M, Ragia G, Panagopoulou M, Balgkouranidou I, Nena E, Kolios G, Papanas N, Manolopoulos VG, Chatzaki E. Search for Pharmacoepigenetic Correlations in Type 2 Diabetes Under Sulfonylurea Treatment. Experimental and Clinical Endocrinology & Diabetes . 2019; 25:217-225.

  • Dovrolis N, Kolios G, Spyrou GM, Maroulakou I. Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disorders. Briefings in Bioinformatics . 2019; 20:825-841.

  • Dovrolis N, Drygiannakis I, Filidou E, Kandilogiannakis L, Arvanitidis K, Tentes I, Kolios G, Valatas V. Gut Microbial Signatures Underline Complicated Crohn's Disease but Vary Between Cohorts; An in Silico Approach. Inflammatory Bowel Diseases . 2019; 25:217-225.

  • Panagopoulou M, Karaglani M, Balgkouranidou I, Pantazi C, Kolios G, Kakolyris S, Chatzaki E. Circulating cell-free DNA release in vitro: kinetics, size profiling, and cancer-related gene methylation. Journal of Cellular Physiology . 2019; 234:14079-14089.

  • Tsaousi G, Stavrou G, Fotiadis K, Kotzampassi K, Kolios G. Implementation of phospholipids as pharmacological modalities for postoperative adhesions prevention. European Journal of Pharmacology . 2019; 842:189-196.

  • Karatzas E, Kolios G, Spyrou GM. An Application of Computational Drug Repurposing Based on Transcriptomic Signatures. Methods in Molecular Biology . 2019; 1903:149-177.

  • Tsekoura M, Ioannidou M, Pana ZD, Haidich AB, Antachopoulos C, Iosifidis E, Kolios G, Roilides E. Efficacy and Safety of Echinocandins for the Treatment of Invasive Candidiasis in Children: A Meta-analysis. Pediatric Infectious Disease Journal . 2019; 38:42-49.

  • Sertaridou EN, Chouvarda IG, Arvanitidis KI, Filidou EK, Kolios GC, Pnevmatikos IN, Papaioannou VE. Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study. Annals of Intensive Care . 2018; 8:118.

  • Fasoulakis Z, Kolios G, Papamanolis V, Kontomanolis EN. Interleukins Associated with Breast Cancer. Cureus . 2018; 10:e3549.

  • Ioannidis A, Arvanitidis K, Filidou E, Valatas V, Stavrou G, Michalopoulos A, Kolios G, Kotzampassi K. The Length of Surgical Skin Incision in Postoperative Inflammatory Reaction. Journal of the Society of Laparoendoscopic Surgeons . 2018; 22. pii: e2018.00045.

  • Filidou E, Valatas V, Drygiannakis I, Arvanitidis K, Vradelis S, Kouklakis G, Kolios G, Bamias G. Cytokine Receptor Profiling in Human Colonic Subepithelial Myofibroblasts: A Differential Effect of Th Polarization-Associated Cytokines in Intestinal Fibrosis. Inflammatory Bowel Diseases . 2018; 24:2224-2241.

  • Stavrou G, Arvanitidis K, Filidou E, Fotiadis K, Grosomanidis V, Ioannidis A, Tsaousi G, Michalopoulos A, Kolios G, Kotzampassi K. Combined Enteral and Parenteral Glutamine Supplementation in Endotoxaemic Swine: Effects on Portal and Systemic Circulation Levels. Medical Principles and Practice . 2018; 27:570-578.

  • Papavramidis TS, Stavrou G, Papakostas P, Grosomanidis V, Kokkota S, Michalopoulos A, Kolios G, Kotzampassi K. Displacement of the Intragastric Balloon from the Fundus to the Antrum Results in Enhanced Weight Loss. Obesity Surgery . 2018; 28:2374-2378.

  • Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA. Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study. Clinical Pharmacology and Therapeutics . 2018; 104:317-325.

  • Gogou M, Kolios G. Are therapeutic diets an emerging additional choice in autism spectrum disorder management? World Journal of Pediatrics . 2018; 14:215-223.

  • Karaglani M, Ragia G, Panagopoulou M, Balgkouranidou I, Nena E, Kolios G, Papanas N, Manolopoulos VG, Chatzaki E. Search for Pharmacoepigenetic Correlations in Type 2 Diabetes Under Sulfonylurea Treatment. Experimental and Clinical Endocrinology & Diabetes . 2018; doi: 10.1055/s-0043-121265.

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