George Kolios MD, PhD
Emeritus Professor of Pharmacology

Laboratory of Pharmacology
Faculty of Medicine, Democritus University of Thrace, Greece
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Βίος ἀνεόρταστος μακρὴ ὁδòς ἀπανδόκευτος
(~460-370 π.Χ.)

Life without feasts is like a long road without an inn
(~460-370 BC)


Telephone+3025510-30368 / Fax +3025510-30541
AddressLaboratory of Pharmacology,
Faculty of Medicine,
Democritus University of Thrace,
Dragana, Alexandroupolis,
68100, Greece.

Curriculum Vitae

English      Ελληνικά

Previous Posts

Research Interests

  • The Role of Subepithelial Myofibroblasts in Mucosal Inflammation and Fibrosis.
  • The Role of Microbiota and its Metabolites in the Pathogenetic Mechanisms of Intestinal Inflammation.
  • Grants
  • Principal Investigator
    “Study of anti-inflammatory and/or anti-fibrotic properties of newly synthesized peptides” (Tithon Biotech Inc, San Diego, California, USA) (2019 - 2025).
  • Principal Investigator
    BBMRI (Biobanking and Biomolecular Resources Research Infrastructure), National Strategic Reference Framework, Greece/European Union (2013 - 2023).
  • Deputy Director
    Individualized Medicine & Pharmacological Research Solutions Center. “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020), co-financed by Greece and the European Union (European Regional Development Fund) (2021-2023).
  • The Center of Excellence for Pharmacology Studies and Precision Medicine IMPReS offers clinical services, applied services and research services in external partners and at the same time promotes the research activities of Medical School in the context of Pharmacology and Medical Precision but also promotes Democritus University of Thrace in general. Moreover, it contributes to the creation of wider collaborations with objectives touching every aspect of Pharmacology.

Selected Publications (Last 5 years)

  • Spathakis M, Filidou E, Pappa C, Arzou BC, Georgiadis A, Kontomanolis EN, Nikolettos N, Kolios G, Galazios G, Arvanitidis K. Spontaneous abortion is associated with differentially expressed angiogenic chemokines in placenta and decidua. Archives of Gynecology and Obstetrics . 2023; 308:821-830.

  • Theodorakis SG, Kolios G, Tzilas V, Bouros D. Influence of inhalation device, active substance, and drug formulation on the compliance of patients with obstructive pulmonary diseases. A physicians' perspective. Pulmonology . 2023; 29:13-19.

  • Anatolou D, Steiropoulos P, Zissimopoulos A, Chadia K, Archontogeorgis K, Kolios G, Manolopoulos VG, Ragia G. Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea. Sleep Breathing 2023. . 2023; doi: 10.1007/s11325-023-02950-w.

  • Atzemian N, Dovrolis N, Ragia G, Portokallidou K, Kolios G, Manolopoulos VG. Beyond the Rhythm: In Silico Identification of Key Genes and Therapeutic Targets in Atrial Fibrillation. Biomedicines . 2023; 11:2632.

  • Ragia G, Maslarinou A, Atzemian N, Biziota E, Koukaki T, Ioannou C, Balgkouranidou I, Kolios G, Kakolyris S, Xenidis N, Amarantidis K, Manolopoulos VG. Implementing pharmacogenetic testing in fluoropyrimidine-treated cancer patients: DPYD genotyping to guide chemotherapy dosing in Greece. Frontiers in Pharmacology . 20234; 14:1248898.

  • Voulgaridou G, Paraskeva T, Ragia G, Atzemian N, Portokallidou K, Kolios G, Arvanitidis K, Manolopoulos VG. Therapeutic Drug Monitoring (TDM) Implementation in Public Hospitals in Greece in 2003 and 2021: A Comparative Analysis of TDM Evolution over the Years. Pharmaceutics . 2023; 15:2181.

  • Spathakis M, Tarapatzi G, Filidou E, Kandilogiannakis L, Karatzas E, Steiropoulos P, Mikroulis D, Spyrou GM, Manolopoulos VG, Kolios G, Arvanitidis K. Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts. Biomedicines . 2023; 11:2032.

  • Dovrolis N, Moschoviti A, Fessatou S, Karamanolis G, Kolios G, Gazouli M. Identifying Microbiome Dynamics in Pediatric IBD: More than a Family Matter. Biomedicines . 2023; 11:1979.

  • Spathakis M, Filidou E, Kolios G, Papazoglou D, Vradelis S. Remission of refractory Crohn's disease with anti-IL-12/23 therapy in a patient undergoing hemodialysis: A case report. Hemodialysis International . 27:E41-E44.

  • Filidou E,Kolios G. Special Issue "Gut Microbiota, Inflammatory Bowel Diseases, and Therapeutic Targets". Pharmaceuticals . 2023; 16(5):714.

  • Panagiotou D, Filidou E, Gaitanidou M, Tarapatzi G, Spathakis M, Kandilogiannakis L, Stavrou G, Arvanitidis K, Tsetis JK, Gionga P, Shrewsbury AD, Manolopoulos VG, Kapoukranidou D, Lasithiotakis K, Kolios G, Kotzampassi K. Role of Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 in the Wound Healing Process of the Excisional Skin. Nutrients . 2023; 15:1822.

  • Filidou E, Kandilogiannakis L, Tarapatzi G, Spathakis M, Su C, Rai A, Greening DW, Arvanitidis K, Paspaliaris V, Kolios G. A Simplified and Effective Approach for the Isolation of Small Pluripotent Stem Cells Derived from Human Peripheral Blood. Biomedicines . 2023; 11:787.

  • Valatas V, Kitamura K, Ward SG, Kolios G. Editorial: Stromal and immune cell interactions in intestinal inflammation and fibrosis. Frontiers in Immunology . 2023; 14:1152140.

  • Portokallidou K, Dovrolis N, Ragia G, Atzemian N, Kolios G, Manolopoulos VG. Multi-omics integration to identify the genetic expression and protein signature of dilated and ischemic cardiomyopathy. Frontiers in Cardiovascular Medicine . 2023; 10:1115623.

  • Dovrolis N, Filidou E, Tarapatzi G, Kokkotis G, Spathakis M, Kandilogiannakis L, Drygiannakis I, Valatas V, Arvanitidis K, Karakasiliotis I, Vradelis S, Manolopoulos VG, Paspaliaris V, Bamias G, Kolios G. Co-expression of fibrotic genes in inflammatory bowel disease; A localized event? Frontiers in Immunology . 2022; 13:1058237.

  • Tarapatzi G, Filidou E, Kandilogiannakis L, Spathakis M, Gaitanidou M, Arvanitidis K, Drygiannakis I, Valatas V, Kotzampassi K, Manolopoulos VG, Kolios G, Vradelis S. The Probiotic Strains Bifidοbacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii Regulate Wound Healing and Chemokine Responses in Human Intestinal Subepithelial Myofibroblasts. Pharmaceuticals . 2022; 15(10):1293.

  • Anatolou D, Dovrolis N, Ragia G, Kolios G, Manolopoulos VG. Unpacking COVID-19 Systems Biology in Lung and Whole Blood with Transcriptomics and miRNA Regulators. OMICS: A Journal of Integrative Biology . 2022; 26:608-621.

  • Katifelis H, Filidou E, Psaraki A, Yakoub F, Roubelakis MG, Tarapatzi G, Vradelis S, Bamias G, Kolios G, Gazouli M. Amniotic Fluid-Derived Mesenchymal Stem/Stromal Cell-Derived Secretome and Exosomes Improve Inflammation in Human Intestinal Subepithelial Myofibroblasts. Biomedicines . 2022; 10:2357.

  • Kolios G, Paspaliaris V. Mesenchyme Stem Cell-Derived Conditioned Medium as a Potential Therapeutic Tool in Idiopathic Pulmonary Fibrosis. Biomedicines . 2022; 10:2298.

  • Gaitanidis A, Kandilogiannakis L, Filidou E, Tsaroucha A, Kolios G, Pitiakoudis M. Stem cell therapies for gastrointestinal anastomotic healing: a systematic review and meta-analysis on results from animal studies. European Surgical Research . 2022; 63:173-181.

  • Papadopoulos C, Mimidis K, Papazoglou D, Kolios G, Tentes I, Anagnostopoulos K. Red Blood Cell-Conditioned Media from Non-Alcoholic Fatty Liver Disease Patients Contain Increased MCP1 and Induce TNF-α Release. Reports of Biochemistry and Molecular Biology . 2022; 11:54-62.

  • Tarapatzi G, Filidou E, Kandilogiannakis L, Kolios G, Vradelis S. Biomarkers in Inflammatory Bowel Diseases: Predicting the Indication and the Effect of Biologics. Journal of Gastrointestinal and Liver Diseases . 2022; 31:229-243.

  • Filidou E, Kandilogiannakis L, Tarapatzi G, Spathakis M, Steiropoulos P, Mikroulis D, Arvanitidis K, Paspaliaris V, Kolios G. Anti-Inflammatory and Anti-Fibrotic Effect of Immortalized Mesenchymal-Stem-Cell-Derived Conditioned Medium on Human Lung Myofibroblasts and Epithelial Cells. International Journal of Molecular Sciences . 2022; 23:4570.

  • Papadopoulos C, Spourita E, Mimidis K, Kolios G, Tentes I, Anagnostopoulos K. Non-alcoholic Fatty Liver Disease Patients Exhibit Reduced CD47 and Increased Sphingosine, Cholesterol, and Monocyte Chemoattractant Protein-1 Levels in the Erythrocyte Membranes. Metabolic Syndrome Related Disorders . 2022; 20:377-383.

  • Gazouli M, Dovrolis N, Bourdakou MM, Gizis M, Kokkotis G, Kolios G, Michalopoulos G, Michopoulos S, Papaconstantinou I, Tzouvala M, Viazis N, Xourafas V, Zacharopoulou E, Zampeli E, Mantzaris G, Papatheodoridis G, Bamias G. Response to Anti-α4β7 Blockade in Patients with Ulcerative Colitis is Associated with Distinct Mucosal Gene Expression Profiles at Baseline. Inflammatory Bowel Diseases . 2022; 28:87-95.

  • Filidou E, Tarapatzi G, Spathakis M, Papadopoulos P, Papadopoulos C, Kandilogiannakis L, Stavrou G, Doumaki E, Sioga A, Meditskou S, Arvanitidis K, Papamitsou T, Grosomanidis V, Kolios G, Kotzampassi K. Post-Cardiac Arrest Syndrome Is Not Associated with An Early Bacterial Translocation. Journal of Surgical Research . 2022; 272:51-60.

  • Filidou E, Kolios G. Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?. Pharmaceuticals . 2021; 14(11):1181.

  • Filidou E, Kandilogiannakis L, Tarapatzi G, Su C, Po ENF, Paspaliaris V, Kolios G. Conditioned medium from a human adipose-derived stem cell line ameliorates inflammation and fibrosis in a lung experimental model of idiopathic pulmonary fibrosis. Life Sciences . 2021; 287:120123.

  • Bourdakou MM, Spyrou GM, Kolios G. Colon Cancer Progression ιs Reflected to Monotonic Differentiation in Gene Expression and Pathway Deregulation Facilitating Stage-specific Drug Repurposing. Cancer Genomics Proteomics . 2021; 18: 757-769.

  • Koutouratsas T, Philippou A, Kolios G, Koutsilieris M, Gazouli M. Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases: A review. World Journal of Gastroenterology . 2021; 27: 5037-5046.

  • Kandilogiannakis L, Filidou E, Drygiannakis I, Tarapatzi G, Didaskalou S, Koffa M, Arvanitidis K, Bamias G, Valatas V, Paspaliaris V, Kolios G. Development of a Human Intestinal Organoid Model for In Vitro Studies on Gut Inflammation and Fibrosis. Stem Cells International . 2021; 2021:9929461.

  • Tomazou M, Bourdakou MM, Minadakis G, Zachariou M, Oulas A, Karatzas E, Loizidou E, Kakouri A, Christodoulou C, Savva K, Zanti M, Onisiforou A, Afxenti S, Richter J, Christodoulou CG, Kyprianou T, Kolios G, Dietis N, Spyrou GM. Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19. Briefings in Bioinformatics . 2021; 2021:9929461.

  • Karamitrousis EI, Balgkouranidou I, Xenidis N, Amarantidis K, Biziota E, Koukaki T, Trypsianis G, Karayiannakis A, Bolanaki H, Kolios G, Lianidou E, Kakolyris S. Prognostic Role of RASSF1A, SOX17 and Wif-1 Promoter Methylation Status in Cell-Free DNA of Advanced Gastric Cancer Patients. Technology in Cancer Research and Treatment . 2021; 20:1533033820973279.

  • Karatzas E, Kakouri AC, Kolios G, Delis A, Spyrou GM. Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action. PLoS One . 2021;16:e0249687.

  • Galaziou A, Filidou E, Spathakis M, Arvanitidis K, Arzou BC, Galazios G, Koutlaki N, Nikolettos N, Kolios G. Imbalance of growth factors mRNA expression associated with oxidative stress in the early pregnancy loss. The Journal of Maternal-Fetal & Neonatal Medicine . 2021; Apr 5;1-7.

  • Kokona D, Spyridakos D, Tzatzarakis M, Papadogkonaki S, Filidou E, Arvanitidis KI, Kolios G, Lamani M, Makriyannis A, Malamas MS, Thermos K. The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity. Neuropharmacology . 2021; 185:108450.

  • Kandilogiannakis L, Filidou E, Kolios G, and Paspaliaris V. Ad-Dressing Stem Cells: Hydrogels for Encapsulation. Processes . 2021; 9,11.

  • Touzopoulos P, Arvanitidis K, Filidou E, Tilkeridis K, Karanikas M, Kolios G, Ververidis A. Is serum gentamicin concentration modified with autologous cell-saved blood transfusion after total knee arthroplasty using tranexamic acid? A randomized control trial. Orthopaedics & Traumatology: Surgery & Research . 2020; 107(3):102794.

  • Karamitrousis E, Balgkouranidou I, Xenidis N, Amarantidis K, Biziota E, Koukaki T, Trypsianis G, Karayiannakis A, Bolanaki H, Chatzaki E, Kolios G, Lianidou E, Lambropoulou M, Kakolyris S. Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer. Clinical Chemistry and Laboratory Medicine . 2020; Online ahead of print.

  • Varbobitis I, Kokkotis G, Gizis M, Perlepe N, Laoudi E, Bletsa M, Bekiari D, Koutsounas I, Kounadis G, Xourafas V, Lagou S, Kolios G, Papakonstantinou I, Bamias G. The IBD-F Patient Self-Assessment Scale Accurately Depicts the Level of Fatigue and Predicts a Negative Effect on the Quality of Life of Patients with IBD in Clinical Remission. Inflammatory Bowel Diseases . 2020; Aug 7;izaa201.

  • Karatzas E, Zachariou M, Bourdakou MM, Minadakis G, Oulas A, Kolios G, Delis A, Spyrou GM. PathWalks: Identifying pathway communities using a disease-related map of integrated information. Bioinformatics . 2020; 36:4070-4079.

  • Koureta M, Karaglani M, Panagopoulou M, Balgkouranidou I, Papadaki-Anastasopoulou A, Zarouchlioti C, Dekavallas S, Kolios G, Lambropoulou M, Baritaki S, Chatzaki E. Corticotropin Releasing Factor Receptors in breast cancer: Expression and activity in hormone-dependent growth in vitro. Peptides . 2020; 129:170316.

  • Dovrolis N, Michalopoulos G, Theodoropoulos GE, Arvanitidis K, Kolios G, Sechi LA, Eliopoulos AG, Gazouli M. The Interplay between Mucosal Microbiota Composition and Host Gene-Expression is Linked with Infliximab Response in Inflammatory Bowel Diseases. Microorganisms . 2020; 8:438.

  • Gogou M, Kolios G. Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone? Journal of the American College of Nutrition . 2020; 39:261-271.

© Page maintained by George Kolios; last updated: 03/2017