Peristera Paschou, PhD

PERISTERA PASCHOU, PhD, DABMG

Lecturer in Population Genetics

           Department of Molecular Biology and Genetics
         Democritus University of Thrace
         University Campus, Bldg 10, Dragana
         Alexandroupoli 68 100, Greece

Tel: +30 25510 30658   Fax: +30 25510 30613
e-mail: ppaschou%mbg.duth.gr (please substitute % for @)

For students...
Slides for the courses I teach can be found at e-class
(Genetics I: spring 2008, Population and Evolutionary Genetics: fall 2008)

Research...
My research interests include genetics of complex disorders as well as the study of population structure and linkage disequilibrium patterns of the human genome across worldwide populations. During my PhD with Fotini Stylianopoulou and Christos Bartsocas at the University of Athens and in collaboration with Cecile Julier at the Wellcome Trust Centre for Human Genetics (University of Oxford), I studied the genetics of type 1 diabetes. More recently, I worked with Kenneth K. Kidd at Yale University, on Tourette Syndrome and explored in collaboration with Petros Drineas at Rensselaer Polytechnic Institute the transferability of tagging SNPs accross different populations as well as the feasibility of genotype reconstruction using tagging SNPs. I am currently working with Elad Ziv at UCSF, on defining the genetic structure of admixed populations using genome-wide data.

Paschou P, Drineas P, Lewis J, Nievergelt CM, Nickerson DA, Smith JD, Ridker PM, Chasman DI, Krauss RM, Ziv E (2008). Tracing sub-structure in the European American population with PCA-informative markers. PLoS Genetics 4(7), e1000114. (pdf - data and info)

Paschou P, Ziv E, Burchard EG, Choudry S, Rodriguez-Cintron W, Mahoney MW, Drineas P (2007). PCA-correlated SNPs for structure identification in worldwide human populations. PLoS Genetics 3, e160. (pdf - data and info)

Paschou P, Mahoney MW, Javed A, Kidd JR, Pakstis AJ, Gu S, Kidd KK, Drineas P (2007). Intra- and Inter-population genotype reconstruction from tagging SNPs. Genome Research 17, 96-107. (pdf - data and info)

Paschou P, Feng Y, Pakstis AJ, Speed WC, DeMille MM, Kidd JR, Jaghori B, Kurlan R, Pauls DL, Sandor P, Barr CL, Kidd KK (2004). Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region. Am J Hum Genet 75,545-560. (pdf)

Hermann R, Bartsocas CS, Soltesz G, Vazeou A, Paschou P, Bozas E, Malamitsi-Puchner A, Simell O, Knip M, Ilonen J (2004). Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence. Diabetes Metab Res Rev 20,322-329. (pdf)

Palmatier MA, Pakstis AJ, Speed W, Paschou P, Goldman D, Odunsi A, Okonofua F, Kajuna S, Karoma N, Kungulilo S, Grigorenko E, Zhukova OV, Bonne-Tamir B, Lu RB, Parnas J, Kidd JR, DeMille MM, Kidd KK (2004). COMT haplotypes suggest P2 promoter region relevance for schizophrenia. Mol Psychiatry 9, 859-870. (pdf)

Paschou P, Bozas E, Dokopoulou M, Havarani B, Malamitsi-Puchner A, Ylli A, Ylli Z, Thymelli I, Gerasimidi-Vazeou A, Bartsocas CS (2004). HLA alleles and type 1 diabetes mellitus in low disease incidence populations of Southern Europe: a comparison of Greeks and Albanians. J Pediatr Endocrinol Metab 17, 173-182. (pdf)

Ilonen J, Sjoroos M, Knip M, Veijola R, Simell O, Akerblom HK, Paschou P, Bozas E, Havarani B, Malamitsi-Puchner A, Thymelli J, Vazeou A, Bartsocas CS (2002). Estimation of genetic risk for type 1 diabetes. Am J Med Genet 115, 30-36. (pdf)